Remaining Challenges in the Treatment of Relapsed Wilms Tumor: Children's Oncology Group and International Society of Paediatric Oncology Perspectives

Kathryn S. Sutton; Amy L. Walz; Alissa Groenendijk; Andrew J. Murphy; Luke Pater; Geert O. Janssens; Jack Brzezinski; Elizabeth A. Mullen; Filippo Spreafico; Jan Godzinski; Justine van der Beek; Marc HWA Wijnen; Marry M. van den Heuvel-Eibrink; Max Pachl; Norbert Graf; Peter F. Ehrlich; Rhoikos Furtwangler; Jesper Brok; James Geller

doi:10.1002/pbc.31790

Remaining Challenges in the Treatment of Relapsed Wilms Tumor: Children's Oncology Group and International Society of Paediatric Oncology Perspectives

Kathryn S. Sutton
, Amy L. Walz
, Alissa Groenendijk
, Andrew J. Murphy
, Luke Pater
, Geert O. Janssens
, Jack Brzezinski
, Elizabeth A. Mullen
, Filippo Spreafico
, Jan Godzinski
, Justine van der Beek
, Marc HWA Wijnen
, Marry M. van den Heuvel-Eibrink
, Max Pachl
, Norbert Graf
, Peter F. Ehrlich
, Rhoikos Furtwangler
, Jesper Brok
, James Geller

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Wilms tumor (WT) is the most common pediatric renal tumor, and with multidisciplinary treatment overall outcomes are excellent. However, a small subset of patients with WT will relapse. The ideal treatment of relapsed WT is yet to be defined. Ongoing studies through the Children's Oncology Group Renal Tumors Committee (COG-RTC) and the International Society of Paediatric Oncology Renal Tumor Study Group (SIOP-RTSG) aim to improve risk stratification and treatment strategies. Members met at the SIOP 55th Annual Congress 2023 to outline available data and knowledge gaps and develop future research priorities.

Original language	English
Article number	e31790
Journal	Pediatric Blood and Cancer
Volume	72
Issue number	8
DOIs	https://doi.org/10.1002/pbc.31790
Publication status	Published - Aug 2025

Keywords

Wilms tumor
renal
solid
tumors
Kidney Neoplasms/therapy
Humans
Neoplasm Recurrence, Local/therapy
Wilms Tumor/therapy
Child

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Sutton, K. S., Walz, A. L., Groenendijk, A., Murphy, A. J., Pater, L., Janssens, G. O., Brzezinski, J., Mullen, E. A., Spreafico, F., Godzinski, J., van der Beek, J., HWA Wijnen, M., van den Heuvel-Eibrink, M. M., Pachl, M., Graf, N., Ehrlich, P. F., Furtwangler, R., Brok, J., & Geller, J. (2025). Remaining Challenges in the Treatment of Relapsed Wilms Tumor: Children's Oncology Group and International Society of Paediatric Oncology Perspectives. Pediatric Blood and Cancer, 72(8), Article e31790. https://doi.org/10.1002/pbc.31790

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title = "Remaining Challenges in the Treatment of Relapsed Wilms Tumor: Children's Oncology Group and International Society of Paediatric Oncology Perspectives",

abstract = "Wilms tumor (WT) is the most common pediatric renal tumor, and with multidisciplinary treatment overall outcomes are excellent. However, a small subset of patients with WT will relapse. The ideal treatment of relapsed WT is yet to be defined. Ongoing studies through the Children's Oncology Group Renal Tumors Committee (COG-RTC) and the International Society of Paediatric Oncology Renal Tumor Study Group (SIOP-RTSG) aim to improve risk stratification and treatment strategies. Members met at the SIOP 55th Annual Congress 2023 to outline available data and knowledge gaps and develop future research priorities.",

keywords = "Wilms tumor, renal, solid, tumors, Kidney Neoplasms/therapy, Humans, Neoplasm Recurrence, Local/therapy, Wilms Tumor/therapy, Child",

author = "Sutton, \{Kathryn S.\} and Walz, \{Amy L.\} and Alissa Groenendijk and Murphy, \{Andrew J.\} and Luke Pater and Janssens, \{Geert O.\} and Jack Brzezinski and Mullen, \{Elizabeth A.\} and Filippo Spreafico and Jan Godzinski and \{van der Beek\}, Justine and \{HWA Wijnen\}, Marc and \{van den Heuvel-Eibrink\}, \{Marry M.\} and Max Pachl and Norbert Graf and Ehrlich, \{Peter F.\} and Rhoikos Furtwangler and Jesper Brok and James Geller",

note = "{\textcopyright} 2025 Wiley Periodicals LLC.",

year = "2025",

month = aug,

doi = "10.1002/pbc.31790",

language = "English",

volume = "72",

journal = "Pediatric Blood and Cancer",

issn = "1545-5009",

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Sutton, KS, Walz, AL, Groenendijk, A, Murphy, AJ, Pater, L, Janssens, GO, Brzezinski, J, Mullen, EA, Spreafico, F, Godzinski, J, van der Beek, J, HWA Wijnen, M , van den Heuvel-Eibrink, MM, Pachl, M, Graf, N, Ehrlich, PF, Furtwangler, R, Brok, J & Geller, J 2025, 'Remaining Challenges in the Treatment of Relapsed Wilms Tumor: Children's Oncology Group and International Society of Paediatric Oncology Perspectives', Pediatric Blood and Cancer, vol. 72, no. 8, e31790. https://doi.org/10.1002/pbc.31790

TY - JOUR

T1 - Remaining Challenges in the Treatment of Relapsed Wilms Tumor

T2 - Children's Oncology Group and International Society of Paediatric Oncology Perspectives

AU - Sutton, Kathryn S.

AU - Walz, Amy L.

AU - Groenendijk, Alissa

AU - Murphy, Andrew J.

AU - Pater, Luke

AU - Janssens, Geert O.

AU - Brzezinski, Jack

AU - Mullen, Elizabeth A.

AU - Spreafico, Filippo

AU - Godzinski, Jan

AU - van der Beek, Justine

AU - HWA Wijnen, Marc

AU - van den Heuvel-Eibrink, Marry M.

AU - Pachl, Max

AU - Graf, Norbert

AU - Ehrlich, Peter F.

AU - Furtwangler, Rhoikos

AU - Brok, Jesper

AU - Geller, James

PY - 2025/8

Y1 - 2025/8

N2 - Wilms tumor (WT) is the most common pediatric renal tumor, and with multidisciplinary treatment overall outcomes are excellent. However, a small subset of patients with WT will relapse. The ideal treatment of relapsed WT is yet to be defined. Ongoing studies through the Children's Oncology Group Renal Tumors Committee (COG-RTC) and the International Society of Paediatric Oncology Renal Tumor Study Group (SIOP-RTSG) aim to improve risk stratification and treatment strategies. Members met at the SIOP 55th Annual Congress 2023 to outline available data and knowledge gaps and develop future research priorities.

AB - Wilms tumor (WT) is the most common pediatric renal tumor, and with multidisciplinary treatment overall outcomes are excellent. However, a small subset of patients with WT will relapse. The ideal treatment of relapsed WT is yet to be defined. Ongoing studies through the Children's Oncology Group Renal Tumors Committee (COG-RTC) and the International Society of Paediatric Oncology Renal Tumor Study Group (SIOP-RTSG) aim to improve risk stratification and treatment strategies. Members met at the SIOP 55th Annual Congress 2023 to outline available data and knowledge gaps and develop future research priorities.

KW - Wilms tumor

KW - renal

KW - solid

KW - tumors

KW - Kidney Neoplasms/therapy

KW - Humans

KW - Neoplasm Recurrence, Local/therapy

KW - Wilms Tumor/therapy

KW - Child

UR - https://www.scopus.com/pages/publications/105005410450

UR - https://www.mendeley.com/catalogue/40cddd00-78aa-3df0-9844-a8eb5e063cc3/

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DO - 10.1002/pbc.31790

M3 - Article

C2 - 40369656

AN - SCOPUS:105005410450

SN - 1545-5009

VL - 72

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

IS - 8

M1 - e31790

ER -

Remaining Challenges in the Treatment of Relapsed Wilms Tumor: Children's Oncology Group and International Society of Paediatric Oncology Perspectives

Abstract

Keywords

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