Repeated isolated limb perfusion in melanoma patients with recurrent in-transit metastases

Jan P. Deroose, Dirk J. Grünhagen, Alexander M.M. Eggermont, Cornelis Verhoef

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


In-transit metastases of melanoma occur in 5-8% of all melanoma patients. In case of extensive locoregional disease, Tumor necrosis factor-α and melphalan-based isolated limb perfusion (TM-ILP) had proven to yield excellent local control. Here, we report on repeat TM-ILP for locoregional recurrence after isolated limb perfusion. Between 1991 and 2013, 37 consecutive repeat TM-ILPs were analyzed in 32 different patients. Three patients underwent a third TM-ILP. During a median follow-up of 20 months after repeat TM-ILP, the overall response rate was 86%. Complete response (CR) was recorded after 24 TM-ILPs (65%). CR after first TM-ILP was a strong predictor for successful repeat TM-ILP in terms of clinical response and local recurrence. Local toxicity was mild (70% Wieberdink I-II). The local recurrence rate was 59%. Five-year overall survival was 35%. Repeat TM-ILP is a safe treatment modality in melanoma patients with recurrent in-transit metastases of melanoma. Those with a CR after first TM-ILP benefit the most from repeat TM-ILP.

Original languageEnglish
Pages (from-to)427-431
Number of pages5
JournalMelanoma Research
Issue number5
Publication statusPublished - 18 Sept 2015
Externally publishedYes


  • isolated limb perfusion
  • melanoma
  • tumor necrosis factor-α


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