Reproductive Complications in Childhood Cancer Survivors

Hanneke M. van Santen; Marianne D. van de Wetering; Annelies M.E. Bos; Marry M. vd Heuvel-Eibrink; Helena J. van der Pal; William Hamish Wallace

doi:10.1016/j.pcl.2020.08.003

Reproductive Complications in Childhood Cancer Survivors

Hanneke M. van Santen, Marianne D. van de Wetering, Annelies M.E. Bos, Marry M. vd Heuvel-Eibrink, Helena J. van der Pal, William Hamish Wallace

Research output: Contribution to journal › Review article › peer-review

22 Citations (Scopus)

Abstract

Gonadal dysfunction and infertility after cancer treatment are major concerns for childhood cancer survivors and their parents. Uncertainty about fertility or being diagnosed with infertility has a negative impact on quality of survival. In this article, determinants of gonadal damage are reviewed and consequences for fertility and pregnancies are discussed. Recommendations for screening and treatment of gonadal function are provided. These should enable timely treatment of gonadal insufficiency aiming to improve linear growth, pubertal development, and sexual functioning. Options for fertility preservation are discussed.

Original language	English
Pages (from-to)	1187-1202
Number of pages	16
Journal	Pediatric Clinics of North America
Volume	67
Issue number	6
DOIs	https://doi.org/10.1016/j.pcl.2020.08.003
Publication status	Published - Dec 2020

Keywords

Childhood cancer survivor
Fertility preservation
Gonadal failure
Infertility
Late effects
Premature ovarian failure
Radiation effects

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10.1016/j.pcl.2020.08.003

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title = "Reproductive Complications in Childhood Cancer Survivors",

abstract = "Gonadal dysfunction and infertility after cancer treatment are major concerns for childhood cancer survivors and their parents. Uncertainty about fertility or being diagnosed with infertility has a negative impact on quality of survival. In this article, determinants of gonadal damage are reviewed and consequences for fertility and pregnancies are discussed. Recommendations for screening and treatment of gonadal function are provided. These should enable timely treatment of gonadal insufficiency aiming to improve linear growth, pubertal development, and sexual functioning. Options for fertility preservation are discussed.",

keywords = "Childhood cancer survivor, Fertility preservation, Gonadal failure, Infertility, Late effects, Premature ovarian failure, Radiation effects",

author = "{van Santen}, {Hanneke M.} and {van de Wetering}, {Marianne D.} and Bos, {Annelies M.E.} and {vd Heuvel-Eibrink}, {Marry M.} and {van der Pal}, {Helena J.} and Wallace, {William Hamish}",

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language = "English",

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T1 - Reproductive Complications in Childhood Cancer Survivors

AU - van Santen, Hanneke M.

AU - van de Wetering, Marianne D.

AU - Bos, Annelies M.E.

AU - vd Heuvel-Eibrink, Marry M.

AU - van der Pal, Helena J.

AU - Wallace, William Hamish

PY - 2020/12

Y1 - 2020/12

N2 - Gonadal dysfunction and infertility after cancer treatment are major concerns for childhood cancer survivors and their parents. Uncertainty about fertility or being diagnosed with infertility has a negative impact on quality of survival. In this article, determinants of gonadal damage are reviewed and consequences for fertility and pregnancies are discussed. Recommendations for screening and treatment of gonadal function are provided. These should enable timely treatment of gonadal insufficiency aiming to improve linear growth, pubertal development, and sexual functioning. Options for fertility preservation are discussed.

AB - Gonadal dysfunction and infertility after cancer treatment are major concerns for childhood cancer survivors and their parents. Uncertainty about fertility or being diagnosed with infertility has a negative impact on quality of survival. In this article, determinants of gonadal damage are reviewed and consequences for fertility and pregnancies are discussed. Recommendations for screening and treatment of gonadal function are provided. These should enable timely treatment of gonadal insufficiency aiming to improve linear growth, pubertal development, and sexual functioning. Options for fertility preservation are discussed.

KW - Childhood cancer survivor

KW - Fertility preservation

KW - Gonadal failure

KW - Infertility

KW - Late effects

KW - Premature ovarian failure

KW - Radiation effects

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U2 - 10.1016/j.pcl.2020.08.003

DO - 10.1016/j.pcl.2020.08.003

M3 - Review article

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AN - SCOPUS:85094213945

SN - 0031-3955

VL - 67

SP - 1187

EP - 1202

JO - Pediatric Clinics of North America

JF - Pediatric Clinics of North America

IS - 6

ER -

Reproductive Complications in Childhood Cancer Survivors

Abstract

Keywords

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