Reproductive Complications in Childhood Cancer Survivors

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17 Citations (Scopus)


Gonadal dysfunction and infertility after cancer treatment are major concerns for childhood cancer survivors and their parents. Uncertainty about fertility or being diagnosed with infertility has a negative impact on quality of survival. In this article, determinants of gonadal damage are reviewed and consequences for fertility and pregnancies are discussed. Recommendations for screening and treatment of gonadal function are provided. These should enable timely treatment of gonadal insufficiency aiming to improve linear growth, pubertal development, and sexual functioning. Options for fertility preservation are discussed.

Original languageEnglish
Pages (from-to)1187-1202
Number of pages16
JournalPediatric Clinics of North America
Issue number6
Publication statusPublished - Dec 2020


  • Childhood cancer survivor
  • Fertility preservation
  • Gonadal failure
  • Infertility
  • Late effects
  • Premature ovarian failure
  • Radiation effects


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