Requirement of cofactors for RXR/RAR-mediated transcriptional activation in vitro

Rafael Valcárcel; Markus Meyer; Michael Meisterernst; Hendrik G. Stunnenberg

doi:10.1016/S0167-4781(96)00234-5

Requirement of cofactors for RXR/RAR-mediated transcriptional activation in vitro

Rafael Valcárcel, Markus Meyer, Michael Meisterernst, Hendrik G. Stunnenberg

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Using crude in vitro systems, we have previously shown that RXR/RAR heterodimers are able to activate transcription from the RAR β2 promoter in a retinoid-dependent manner. Here we demonstrate that cofactors distinct from general transcription factors or receptors are required to mediate retinoic acid-dependent transcription in vitro.

Original language	English
Pages (from-to)	229-234
Number of pages	6
Journal	BBA - Gene Structure and Expression
Volume	1350
Issue number	3
DOIs	https://doi.org/10.1016/S0167-4781(96)00234-5
Publication status	Published - 28 Mar 1997
Externally published	Yes

Keywords

cofactor
heterodimer RXR/RAR
RAR β2 promoter
transcription

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10.1016/S0167-4781(96)00234-5

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title = "Requirement of cofactors for RXR/RAR-mediated transcriptional activation in vitro",

abstract = "Using crude in vitro systems, we have previously shown that RXR/RAR heterodimers are able to activate transcription from the RAR β2 promoter in a retinoid-dependent manner. Here we demonstrate that cofactors distinct from general transcription factors or receptors are required to mediate retinoic acid-dependent transcription in vitro.",

keywords = "cofactor, heterodimer RXR/RAR, RAR β2 promoter, transcription",

author = "Rafael Valc{\'a}rcel and Markus Meyer and Michael Meisterernst and Stunnenberg, {Hendrik G.}",

note = "Funding Information: We thank Paolo Ciana, Elisenda Ferrer and Juan Valcfircel for careful review of the manuscript. R.V. was supported by an European Molecular Biology Organization fellowship.",

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T1 - Requirement of cofactors for RXR/RAR-mediated transcriptional activation in vitro

AU - Valcárcel, Rafael

AU - Meyer, Markus

AU - Meisterernst, Michael

AU - Stunnenberg, Hendrik G.

N1 - Funding Information: We thank Paolo Ciana, Elisenda Ferrer and Juan Valcfircel for careful review of the manuscript. R.V. was supported by an European Molecular Biology Organization fellowship.

PY - 1997/3/28

Y1 - 1997/3/28

N2 - Using crude in vitro systems, we have previously shown that RXR/RAR heterodimers are able to activate transcription from the RAR β2 promoter in a retinoid-dependent manner. Here we demonstrate that cofactors distinct from general transcription factors or receptors are required to mediate retinoic acid-dependent transcription in vitro.

AB - Using crude in vitro systems, we have previously shown that RXR/RAR heterodimers are able to activate transcription from the RAR β2 promoter in a retinoid-dependent manner. Here we demonstrate that cofactors distinct from general transcription factors or receptors are required to mediate retinoic acid-dependent transcription in vitro.

KW - cofactor

KW - heterodimer RXR/RAR

KW - RAR β2 promoter

KW - transcription

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U2 - 10.1016/S0167-4781(96)00234-5

DO - 10.1016/S0167-4781(96)00234-5

M3 - Article

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AN - SCOPUS:0031588972

SN - 0167-4781

VL - 1350

SP - 229

EP - 234

JO - BBA - Gene Structure and Expression

JF - BBA - Gene Structure and Expression

IS - 3

ER -

Requirement of cofactors for RXR/RAR-mediated transcriptional activation in vitro

Abstract

Keywords

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