Respiratoir syncytieel virus bronchiolitis: Rol van genetische polymorfismen

Translated title of the contribution: Respiratory syncytical virus bronchiolitis: The role of genetic polymorphism

Jan L.L. Kimpen, Grada M. Van Bleek, Louis J. Bont, Tjeerd Kimman, Barbara Hoebee

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

The variability in disease severity after infection with respiratory syncytial virus (RSV), and the risk for recurrent wheezing after the initial episode, is influenced by a number of epidemiologic and demographic factors including the month of birth, smoking in the household, and a medical history of prematurity, chronic lung disease or congenital heart defects. Next to these factors, outcome of infection is probably influenced by genetic polymorphisms in genes encoding for proteins playing a role in the immune response. Some of these polymorphisms have been studied in detail and correlated with severity of RSV-induced disease. Unfortunately functional correlates of these polymorphisms are still lacking. Thus far the clinical relevance of these polymorphisms as prognostic factors is unclear.

Translated title of the contributionRespiratory syncytical virus bronchiolitis: The role of genetic polymorphism
Original languageDutch
Pages (from-to)157-163
Number of pages7
JournalTijdschrift voor Kindergeneeskunde
Volume72
Issue number5
Publication statusPublished - Oct 2004
Externally publishedYes

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