Screening of the central nervous system in children with invasive pulmonary aspergillosis

Emmi Broenen; Annelies Mavinkurve-Groothuis; Karin Kamphuis-Van Ulzen; Roger Brüggemann; Paul Verweij; Adilia Warris

doi:10.1016/j.mmcr.2014.02.001

Screening of the central nervous system in children with invasive pulmonary aspergillosis

Emmi Broenen
, Annelies Mavinkurve-Groothuis
, Karin Kamphuis-Van Ulzen
, Roger Brüggemann
, Paul Verweij
, Adilia Warris

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

The existing guidelines regarding the management of invasive pulmonary aspergillosis do not recommend screening of the extra-pulmonary sites. Due to the fact that the presence of central nervous system (CNS) aspergillosis will influence treatment decisions regarding which antifungal to use and the aimed target concentrations of azoles in plasma, to be informed about dissemination of the infection to the CNS is absolutely necessary. We demonstrate the need for a structured approach to screening of pediatric patients for CNS aspergillosis.

Original language	English
Pages (from-to)	8-11
Number of pages	4
Journal	Medical Mycology Case Reports
Volume	4
Issue number	1
DOIs	https://doi.org/10.1016/j.mmcr.2014.02.001
Publication status	Published - Apr 2014
Externally published	Yes

Keywords

Aspergillosis
Central nervous system
Pediatrics
Screening
Therapeutic drug monitoring
Voriconazole

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10.1016/j.mmcr.2014.02.001

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title = "Screening of the central nervous system in children with invasive pulmonary aspergillosis",

abstract = "The existing guidelines regarding the management of invasive pulmonary aspergillosis do not recommend screening of the extra-pulmonary sites. Due to the fact that the presence of central nervous system (CNS) aspergillosis will influence treatment decisions regarding which antifungal to use and the aimed target concentrations of azoles in plasma, to be informed about dissemination of the infection to the CNS is absolutely necessary. We demonstrate the need for a structured approach to screening of pediatric patients for CNS aspergillosis.",

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author = "Emmi Broenen and Annelies Mavinkurve-Groothuis and \{Kamphuis-Van Ulzen\}, Karin and Roger Br{\"u}ggemann and Paul Verweij and Adilia Warris",

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AU - Broenen, Emmi

AU - Mavinkurve-Groothuis, Annelies

AU - Kamphuis-Van Ulzen, Karin

AU - Brüggemann, Roger

AU - Verweij, Paul

AU - Warris, Adilia

PY - 2014/4

Y1 - 2014/4

N2 - The existing guidelines regarding the management of invasive pulmonary aspergillosis do not recommend screening of the extra-pulmonary sites. Due to the fact that the presence of central nervous system (CNS) aspergillosis will influence treatment decisions regarding which antifungal to use and the aimed target concentrations of azoles in plasma, to be informed about dissemination of the infection to the CNS is absolutely necessary. We demonstrate the need for a structured approach to screening of pediatric patients for CNS aspergillosis.

AB - The existing guidelines regarding the management of invasive pulmonary aspergillosis do not recommend screening of the extra-pulmonary sites. Due to the fact that the presence of central nervous system (CNS) aspergillosis will influence treatment decisions regarding which antifungal to use and the aimed target concentrations of azoles in plasma, to be informed about dissemination of the infection to the CNS is absolutely necessary. We demonstrate the need for a structured approach to screening of pediatric patients for CNS aspergillosis.

KW - Aspergillosis

KW - Central nervous system

KW - Pediatrics

KW - Screening

KW - Therapeutic drug monitoring

KW - Voriconazole

UR - https://www.scopus.com/pages/publications/84896845159

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ER -

Screening of the central nervous system in children with invasive pulmonary aspergillosis

Abstract

Keywords

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