Sealing the gap between nuclear DNA damage and longevity

Björn Schumacher; Jan H. Hoeijmakers; George A. Garinis

doi:10.1016/j.mce.2008.10.031

Sealing the gap between nuclear DNA damage and longevity

Björn Schumacher, Jan H. Hoeijmakers, George A. Garinis

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

A number of progeroid syndromes with defects in the cellular response to DNA damage suggest that progressive genome instability represents an important aspect of the aging process. Here, we review a number of mouse models for progeroid syndromes that are caused by inherited defects in nucleotide excision repair and are characterized by rapid onset of aging symptoms and premature death. We argue that alterations in genome maintenance pathways impact complex physiological processes that may affect the onset of clinically defined age-related pathologies, including cancer as well as pathways that are normally associated with longevity.

Original language	English
Pages (from-to)	112-117
Number of pages	6
Journal	Molecular and Cellular Endocrinology
Volume	299
Issue number	1
DOIs	https://doi.org/10.1016/j.mce.2008.10.031
Publication status	Published - 5 Feb 2009
Externally published	Yes

Keywords

DNA damage
Longevity
Progeria

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10.1016/j.mce.2008.10.031

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title = "Sealing the gap between nuclear DNA damage and longevity",

abstract = "A number of progeroid syndromes with defects in the cellular response to DNA damage suggest that progressive genome instability represents an important aspect of the aging process. Here, we review a number of mouse models for progeroid syndromes that are caused by inherited defects in nucleotide excision repair and are characterized by rapid onset of aging symptoms and premature death. We argue that alterations in genome maintenance pathways impact complex physiological processes that may affect the onset of clinically defined age-related pathologies, including cancer as well as pathways that are normally associated with longevity.",

keywords = "DNA damage, Longevity, Progeria",

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note = "Funding Information: This work is supported by the Netherlands Organization for Scientific Research (NWO) through the foundation of the Research Institute Diseases of the Elderly, as well as grants from SenterNovem IOP-Genomics (IGE03009), NIH (1PO1 AG17242-02), NIEHS (1UO1 ES011044), EC (QRTL-1999-02002), and the Dutch Cancer Society (EUR 99-2004). B.S. is supported by EMBO and Marie Curie fellowships and a Veni (NWO) grant.",

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AU - Garinis, George A.

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Sealing the gap between nuclear DNA damage and longevity

Abstract

Keywords

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