Secondary meningioma in a long-term survivor of atypical teratoid/ rhabdoid tumour with a germline INI1 mutation

A. C.J. Ammerlaan; M. P.W.A. Houben; C. C. Tijssen; P. Wesseling; T. J.M. Hulsebos

doi:10.1007/s00381-007-0578-0

Secondary meningioma in a long-term survivor of atypical teratoid/ rhabdoid tumour with a germline INI1 mutation

A. C.J. Ammerlaan, M. P.W.A. Houben, C. C. Tijssen, P. Wesseling, T. J.M. Hulsebos

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Objective: We report on a patient who developed a meningioma more than two decades after removal at a young age of an atypical teratoid/ rhabdoid tumour (AT/RT), which was due to a germline INI1 mutation, and radio- and chemotherapy. Materials and methods: We present genetic evidence that the meningioma is not a recurrence or metastasis of the AT/RT and not due to the INI1 mutation, but is a radiation-induced tumour. Conclusion: This is the first case illustrating that improved survival of young patients with an AT/RT after aggressive treatment may be gained at the cost of an increased risk for the development of radiation-induced, non-INI1-related tumours.

Original language	English
Pages (from-to)	855-857
Number of pages	3
Journal	Child's Nervous System
Volume	24
Issue number	7
DOIs	https://doi.org/10.1007/s00381-007-0578-0
Publication status	Published - Jul 2008
Externally published	Yes

Keywords

Atypical teratoid/rhabdoid tumour
Genetic predisposition
INI1
Meningioma
Radiation therapy

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10.1007/s00381-007-0578-0

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@article{aa247536a4214ade8127a18ee2a0c132,

title = "Secondary meningioma in a long-term survivor of atypical teratoid/ rhabdoid tumour with a germline INI1 mutation",

abstract = "Objective: We report on a patient who developed a meningioma more than two decades after removal at a young age of an atypical teratoid/ rhabdoid tumour (AT/RT), which was due to a germline INI1 mutation, and radio- and chemotherapy. Materials and methods: We present genetic evidence that the meningioma is not a recurrence or metastasis of the AT/RT and not due to the INI1 mutation, but is a radiation-induced tumour. Conclusion: This is the first case illustrating that improved survival of young patients with an AT/RT after aggressive treatment may be gained at the cost of an increased risk for the development of radiation-induced, non-INI1-related tumours.",

keywords = "Atypical teratoid/rhabdoid tumour, Genetic predisposition, INI1, Meningioma, Radiation therapy",

author = "Ammerlaan, {A. C.J.} and Houben, {M. P.W.A.} and Tijssen, {C. C.} and P. Wesseling and Hulsebos, {T. J.M.}",

note = "Funding Information: Acknowledgement We gratefully acknowledge the financial support from the Dutch Cancer Society, grants KUN 2003-2975 (PW) and UVA 2001-2561 (TH).",

year = "2008",

month = jul,

doi = "10.1007/s00381-007-0578-0",

language = "English",

volume = "24",

pages = "855--857",

journal = "Child's Nervous System",

issn = "0256-7040",

publisher = "Springer Verlag",

number = "7",

}

TY - JOUR

T1 - Secondary meningioma in a long-term survivor of atypical teratoid/ rhabdoid tumour with a germline INI1 mutation

AU - Ammerlaan, A. C.J.

AU - Houben, M. P.W.A.

AU - Tijssen, C. C.

AU - Wesseling, P.

AU - Hulsebos, T. J.M.

N1 - Funding Information: Acknowledgement We gratefully acknowledge the financial support from the Dutch Cancer Society, grants KUN 2003-2975 (PW) and UVA 2001-2561 (TH).

PY - 2008/7

Y1 - 2008/7

N2 - Objective: We report on a patient who developed a meningioma more than two decades after removal at a young age of an atypical teratoid/ rhabdoid tumour (AT/RT), which was due to a germline INI1 mutation, and radio- and chemotherapy. Materials and methods: We present genetic evidence that the meningioma is not a recurrence or metastasis of the AT/RT and not due to the INI1 mutation, but is a radiation-induced tumour. Conclusion: This is the first case illustrating that improved survival of young patients with an AT/RT after aggressive treatment may be gained at the cost of an increased risk for the development of radiation-induced, non-INI1-related tumours.

AB - Objective: We report on a patient who developed a meningioma more than two decades after removal at a young age of an atypical teratoid/ rhabdoid tumour (AT/RT), which was due to a germline INI1 mutation, and radio- and chemotherapy. Materials and methods: We present genetic evidence that the meningioma is not a recurrence or metastasis of the AT/RT and not due to the INI1 mutation, but is a radiation-induced tumour. Conclusion: This is the first case illustrating that improved survival of young patients with an AT/RT after aggressive treatment may be gained at the cost of an increased risk for the development of radiation-induced, non-INI1-related tumours.

KW - Atypical teratoid/rhabdoid tumour

KW - Genetic predisposition

KW - INI1

KW - Meningioma

KW - Radiation therapy

UR - http://www.scopus.com/inward/record.url?scp=44649171111&partnerID=8YFLogxK

U2 - 10.1007/s00381-007-0578-0

DO - 10.1007/s00381-007-0578-0

M3 - Article

C2 - 18236049

AN - SCOPUS:44649171111

SN - 0256-7040

VL - 24

SP - 855

EP - 857

JO - Child's Nervous System

JF - Child's Nervous System

IS - 7

ER -

Secondary meningioma in a long-term survivor of atypical teratoid/ rhabdoid tumour with a germline INI1 mutation

Abstract

Keywords

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