TY - JOUR
T1 - Serum lactate dehydrogenase isoenzyme 1 activity in patients with testicular germ cell tumors correlates with the total number of copies of the short arm of chromosome 12 in the tumor
AU - von Eyben, Finn Edler
AU - de Graaff, Willem E.
AU - Marrink, Jan
AU - Blaabjerg, Ole
AU - Sleijfer, Dirk Th
AU - Koops, Heimen Schraffordt
AU - Oosterhuis, J. Wolter
AU - Petersen, Per Hyltoft
AU - van Echten-Arends, Jannie
AU - de Jong, Bauke
PY - 1992/10
Y1 - 1992/10
N2 - The aim of our study was to assess the relationship between the serum lactate dehydrogenase isoenzyme 1 (S-LDH-1) activity in patients with testicular germ cell tumors and the number of copies of the short arm of chromosome 12 (12p) present in tumor. Twenty-seven adult patients with measurable tumor lesions were studied. Twenty-five had three or more copies of chromosome 12 per cell in the tumors. Nineteen had one or more copies of a specific chromosomal abnormality, an isochromosome of the short arm of chromosome 12, i(12p). Fourteen had increased S-LDH-1 levels. S-LDH-1 activity correlated significantly with the product of total tumor volume and the total number of copies of the short arm of chromosome 12 present per cell (total tumor 12p). We conclude that the total number of copies of the short arm of chromosome 12 in the tumors is most probably a factor contributing to the LDH-1 activity released from the tumors.
AB - The aim of our study was to assess the relationship between the serum lactate dehydrogenase isoenzyme 1 (S-LDH-1) activity in patients with testicular germ cell tumors and the number of copies of the short arm of chromosome 12 (12p) present in tumor. Twenty-seven adult patients with measurable tumor lesions were studied. Twenty-five had three or more copies of chromosome 12 per cell in the tumors. Nineteen had one or more copies of a specific chromosomal abnormality, an isochromosome of the short arm of chromosome 12, i(12p). Fourteen had increased S-LDH-1 levels. S-LDH-1 activity correlated significantly with the product of total tumor volume and the total number of copies of the short arm of chromosome 12 present per cell (total tumor 12p). We conclude that the total number of copies of the short arm of chromosome 12 in the tumors is most probably a factor contributing to the LDH-1 activity released from the tumors.
KW - Cytogenetics
KW - Lactate dehydrogenase isoenzymes
KW - Testicular neoplasms
UR - http://www.scopus.com/inward/record.url?scp=0026449019&partnerID=8YFLogxK
U2 - 10.1007/BF00286191
DO - 10.1007/BF00286191
M3 - Article
C2 - 1435725
AN - SCOPUS:0026449019
SN - 0026-8925
VL - 235
SP - 140
EP - 146
JO - MGG Molecular & General Genetics
JF - MGG Molecular & General Genetics
IS - 1
ER -