Severe skin toxicity in pediatric oncology patients treated with voriconazole and concomitant methotrexate

Johan G.C. Van Hasselt; Natasha K.A. Van Eijkelenburg; Alwin D.R. Huitema; Jan H.M. Schellens; Antoinette Y.N. Schouten-Van Meeteren

doi:10.1128/AAC.00068-13

Severe skin toxicity in pediatric oncology patients treated with voriconazole and concomitant methotrexate

Johan G.C. Van Hasselt
, Natasha K.A. Van Eijkelenburg
, Alwin D.R. Huitema
, Jan H.M. Schellens
, Antoinette Y.N. Schouten-Van Meeteren

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

We report the occurrence of skin toxicities in pediatric oncology patients on concomitant treatment with voriconazole and methotrexate (MTX). Of 23 patients who received this combination, 11 patients suffered from cheilitis and/or photosensitivity. In contrast, only in 1 of 9 patients who received voriconazole without MTX was photosensitivity observed. A mechanism of action was not able to be identified. We describe two cases with severe skin toxicities. Caution is warranted when using voriconazole and concomitant MTX.

Original language	English
Pages (from-to)	2878-2881
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	57
Issue number	6
DOIs	https://doi.org/10.1128/AAC.00068-13
Publication status	Published - Jun 2013
Externally published	Yes

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title = "Severe skin toxicity in pediatric oncology patients treated with voriconazole and concomitant methotrexate",

abstract = "We report the occurrence of skin toxicities in pediatric oncology patients on concomitant treatment with voriconazole and methotrexate (MTX). Of 23 patients who received this combination, 11 patients suffered from cheilitis and/or photosensitivity. In contrast, only in 1 of 9 patients who received voriconazole without MTX was photosensitivity observed. A mechanism of action was not able to be identified. We describe two cases with severe skin toxicities. Caution is warranted when using voriconazole and concomitant MTX.",

author = "\{Van Hasselt\}, \{Johan G.C.\} and \{Van Eijkelenburg\}, \{Natasha K.A.\} and Huitema, \{Alwin D.R.\} and Schellens, \{Jan H.M.\} and \{Schouten-Van Meeteren\}, \{Antoinette Y.N.\}",

year = "2013",

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AU - Van Hasselt, Johan G.C.

AU - Van Eijkelenburg, Natasha K.A.

AU - Huitema, Alwin D.R.

AU - Schellens, Jan H.M.

AU - Schouten-Van Meeteren, Antoinette Y.N.

PY - 2013/6

Y1 - 2013/6

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AB - We report the occurrence of skin toxicities in pediatric oncology patients on concomitant treatment with voriconazole and methotrexate (MTX). Of 23 patients who received this combination, 11 patients suffered from cheilitis and/or photosensitivity. In contrast, only in 1 of 9 patients who received voriconazole without MTX was photosensitivity observed. A mechanism of action was not able to be identified. We describe two cases with severe skin toxicities. Caution is warranted when using voriconazole and concomitant MTX.

UR - https://www.scopus.com/pages/publications/84877842921

U2 - 10.1128/AAC.00068-13

DO - 10.1128/AAC.00068-13

M3 - Article

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AN - SCOPUS:84877842921

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JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 6

ER -

Severe skin toxicity in pediatric oncology patients treated with voriconazole and concomitant methotrexate

Abstract

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