Short-term, combined fasting and exercise improves body composition in healthy males

Giuseppe delli Paoli, Denise van de Laarschot, Edith C.H. Friesema, Remco Verkaik, Antonia Giacco, Rosalba Senese, Pascal P. Arp, P. Mila Jhamai, Stefano M. Pagnotta, Linda Broer, André G. Uitterlinden, Antonia Lanni, M. Carola Zillikens, Pieter de Lange

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Fasting enhances the beneficial metabolic outcomes of exercise; however, it is unknown whether body composition is favorably modified on the short term. A baseline-follow-up study was carried out to assess the effect of an established protocol involving short-term combined exercise with fasting on body composition. One hundred seven recreationally exercising males underwent a 10-day intervention across 15 fitness centers in the Netherlands involving a 3-day gradual decrease of food intake, a 3-day period with extremely low caloric intake, and a gradual 4-day increase to initial caloric intake, with daily 30-min submaximal cycling. Using dual-energy X-ray absorptiometry analysis, all subjects substantially lost total body mass (−3.9 ± 1.9 kg; p < .001) and fat mass (−3.3 ± 1.3 kg; p < .001). Average lean mass was lost (−0.6 ± 1.5 kg; p < .001), but lean mass as a percentage of total body mass was not reduced. The authors observed a loss of −3.9 ± 1.9% android fat over total fat mass (p < .001), a loss of −2.2 ± 1.9% gynoid over total fat mass (p < .001), and reduced android/gynoid ratios (−0.05 ± 0.1; p < .001). Analyzing 15 preselected single-nucleotide polymorphisms in 13 metabolism-related genes revealed trending associations for thyroid state-related single-nucleotide polymorphisms rs225014 (deiodinase 2) and rs35767 (insulin-like growth factor1), and rs1053049 (PPARD). In conclusion, a short period of combined fasting and exercise leads to a substantial loss of body and fat mass without a loss of lean mass as a percentage of total mass.

Original languageEnglish
Pages (from-to)386-395
Number of pages10
JournalInternational Journal of Sport Nutrition and Exercise Metabolism
Volume30
Issue number6
DOIs
Publication statusPublished - Nov 2020
Externally publishedYes

Keywords

  • DXA scan
  • Male subjects
  • SNPs

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