Signaling Mucins in the (S)limelight

Hans Clevers

doi:10.1016/j.devcel.2004.07.013

Signaling Mucins in the (S)limelight

Hans Clevers

Research output: Contribution to journal › Review article › peer-review

5 Citations (Scopus)

Abstract

Mucins may be the ugly ducklings of molecular biology. Their large size, repetitive nature, and unglamorous biological activities have not favored their study. However, integral membrane mucins have conserved intracellular C termini that may influence intracellular signaling. In a recent issue of Genes & Development, Cullen et al. show that the C terminus of membrane mucin-like Msb2 activates a CDC42/MAPK cascade to control filamentous growth of baker's yeast.

Original language	English
Pages (from-to)	150-151
Number of pages	2
Journal	Developmental Cell
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/j.devcel.2004.07.013
Publication status	Published - Aug 2004
Externally published	Yes

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10.1016/j.devcel.2004.07.013

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title = "Signaling Mucins in the (S)limelight",

abstract = "Mucins may be the ugly ducklings of molecular biology. Their large size, repetitive nature, and unglamorous biological activities have not favored their study. However, integral membrane mucins have conserved intracellular C termini that may influence intracellular signaling. In a recent issue of Genes \& Development, Cullen et al. show that the C terminus of membrane mucin-like Msb2 activates a CDC42/MAPK cascade to control filamentous growth of baker's yeast.",

author = "Hans Clevers",

year = "2004",

month = aug,

doi = "10.1016/j.devcel.2004.07.013",

language = "English",

volume = "7",

pages = "150--151",

journal = "Developmental Cell",

issn = "1534-5807",

publisher = "Cell Press",

number = "2",

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T1 - Signaling Mucins in the (S)limelight

AU - Clevers, Hans

PY - 2004/8

Y1 - 2004/8

N2 - Mucins may be the ugly ducklings of molecular biology. Their large size, repetitive nature, and unglamorous biological activities have not favored their study. However, integral membrane mucins have conserved intracellular C termini that may influence intracellular signaling. In a recent issue of Genes & Development, Cullen et al. show that the C terminus of membrane mucin-like Msb2 activates a CDC42/MAPK cascade to control filamentous growth of baker's yeast.

AB - Mucins may be the ugly ducklings of molecular biology. Their large size, repetitive nature, and unglamorous biological activities have not favored their study. However, integral membrane mucins have conserved intracellular C termini that may influence intracellular signaling. In a recent issue of Genes & Development, Cullen et al. show that the C terminus of membrane mucin-like Msb2 activates a CDC42/MAPK cascade to control filamentous growth of baker's yeast.

UR - https://www.scopus.com/pages/publications/4344594045

U2 - 10.1016/j.devcel.2004.07.013

DO - 10.1016/j.devcel.2004.07.013

M3 - Review article

C2 - 15296711

AN - SCOPUS:4344594045

SN - 1534-5807

VL - 7

SP - 150

EP - 151

JO - Developmental Cell

JF - Developmental Cell

IS - 2

ER -

Signaling Mucins in the (S)limelight

Abstract

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