Skeletal Muscle Ultrasound: Correlation Between Fibrous Tissue and Echo Intensity

Sigrid Pillen; Ramon O. Tak; Machiel J. Zwarts; Martin M.Y. Lammens; Kiek N. Verrijp; Ilse M.P. Arts; Jeroen A. van der Laak; Peter M. Hoogerbrugge; Baziel G.M. van Engelen; Aad Verrips

doi:10.1016/j.ultrasmedbio.2008.09.016

Skeletal Muscle Ultrasound: Correlation Between Fibrous Tissue and Echo Intensity

Sigrid Pillen, Ramon O. Tak, Machiel J. Zwarts, Martin M.Y. Lammens, Kiek N. Verrijp, Ilse M.P. Arts, Jeroen A. van der Laak, Peter M. Hoogerbrugge, Baziel G.M. van Engelen, Aad Verrips

Research output: Contribution to journal › Article › peer-review

212 Citations (Scopus)

Abstract

In this study, we examined the correlation between muscle ultrasound and muscle structure. Echo intensity (EI) of 14 muscles of two golden retriever muscular dystrophy dogs was correlated to the percentage interstitial fibrous tissue and fat in muscle biopsy. A significant correlation between interstitial fibrous tissue and EI was found (r = 0.87; p < 0.001). The separate influence of interstitial fat on muscle EI could not be established as only little fat was present. We conclude that fibrous tissue causes increased muscle EI. The high correlation between interstitial fibrous tissue and EI makes ultrasound a reliable method to determine severity of structural muscle changes. (E-mail: s.pillen@cukz.umcn.nl).

Original language	English
Pages (from-to)	443-446
Number of pages	4
Journal	Ultrasound in Medicine and Biology
Volume	35
Issue number	3
DOIs	https://doi.org/10.1016/j.ultrasmedbio.2008.09.016
Publication status	Published - Mar 2009
Externally published	Yes

Keywords

Dogs
Duchenne muscular dystrophy
Echo intensity
Muscle
Neuromuscular disorders
Ultrasound

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10.1016/j.ultrasmedbio.2008.09.016

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@article{377299be7d714682b90396c5a47baf45,

title = "Skeletal Muscle Ultrasound: Correlation Between Fibrous Tissue and Echo Intensity",

abstract = "In this study, we examined the correlation between muscle ultrasound and muscle structure. Echo intensity (EI) of 14 muscles of two golden retriever muscular dystrophy dogs was correlated to the percentage interstitial fibrous tissue and fat in muscle biopsy. A significant correlation between interstitial fibrous tissue and EI was found (r = 0.87; p < 0.001). The separate influence of interstitial fat on muscle EI could not be established as only little fat was present. We conclude that fibrous tissue causes increased muscle EI. The high correlation between interstitial fibrous tissue and EI makes ultrasound a reliable method to determine severity of structural muscle changes. (E-mail: s.pillen@cukz.umcn.nl).",

keywords = "Dogs, Duchenne muscular dystrophy, Echo intensity, Muscle, Neuromuscular disorders, Ultrasound",

author = "Sigrid Pillen and Tak, {Ramon O.} and Zwarts, {Machiel J.} and Lammens, {Martin M.Y.} and Verrijp, {Kiek N.} and Arts, {Ilse M.P.} and {van der Laak}, {Jeroen A.} and Hoogerbrugge, {Peter M.} and {van Engelen}, {Baziel G.M.} and Aad Verrips",

note = "Funding Information: The authors thank the University of Missouri for providing the GRMD carrier dam and semen and Nens van Alfen, MD, PhD, for her critical reading of the manuscript. The study was supported by a grant from the Prinses Beatrix Fonds (No. MAR02–0105) and a grant form The Netherlands Organization for Health Research and Development (ZonMw No. 907 to 00–057).",

year = "2009",

month = mar,

doi = "10.1016/j.ultrasmedbio.2008.09.016",

language = "English",

volume = "35",

pages = "443--446",

journal = "Ultrasound in Medicine and Biology",

issn = "0301-5629",

publisher = "Elsevier USA",

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TY - JOUR

T1 - Skeletal Muscle Ultrasound

T2 - Correlation Between Fibrous Tissue and Echo Intensity

AU - Pillen, Sigrid

AU - Tak, Ramon O.

AU - Zwarts, Machiel J.

AU - Lammens, Martin M.Y.

AU - Verrijp, Kiek N.

AU - Arts, Ilse M.P.

AU - van der Laak, Jeroen A.

AU - Hoogerbrugge, Peter M.

AU - van Engelen, Baziel G.M.

AU - Verrips, Aad

N1 - Funding Information: The authors thank the University of Missouri for providing the GRMD carrier dam and semen and Nens van Alfen, MD, PhD, for her critical reading of the manuscript. The study was supported by a grant from the Prinses Beatrix Fonds (No. MAR02–0105) and a grant form The Netherlands Organization for Health Research and Development (ZonMw No. 907 to 00–057).

PY - 2009/3

Y1 - 2009/3

N2 - In this study, we examined the correlation between muscle ultrasound and muscle structure. Echo intensity (EI) of 14 muscles of two golden retriever muscular dystrophy dogs was correlated to the percentage interstitial fibrous tissue and fat in muscle biopsy. A significant correlation between interstitial fibrous tissue and EI was found (r = 0.87; p < 0.001). The separate influence of interstitial fat on muscle EI could not be established as only little fat was present. We conclude that fibrous tissue causes increased muscle EI. The high correlation between interstitial fibrous tissue and EI makes ultrasound a reliable method to determine severity of structural muscle changes. (E-mail: s.pillen@cukz.umcn.nl).

AB - In this study, we examined the correlation between muscle ultrasound and muscle structure. Echo intensity (EI) of 14 muscles of two golden retriever muscular dystrophy dogs was correlated to the percentage interstitial fibrous tissue and fat in muscle biopsy. A significant correlation between interstitial fibrous tissue and EI was found (r = 0.87; p < 0.001). The separate influence of interstitial fat on muscle EI could not be established as only little fat was present. We conclude that fibrous tissue causes increased muscle EI. The high correlation between interstitial fibrous tissue and EI makes ultrasound a reliable method to determine severity of structural muscle changes. (E-mail: s.pillen@cukz.umcn.nl).

KW - Dogs

KW - Duchenne muscular dystrophy

KW - Echo intensity

KW - Muscle

KW - Neuromuscular disorders

KW - Ultrasound

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JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

IS - 3

ER -

Skeletal Muscle Ultrasound: Correlation Between Fibrous Tissue and Echo Intensity

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Keywords

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