Strategies for epigenome analysis

A. B. Brinkman; H. G. Stunnenberg

doi:10.1007/978-1-4020-9187-2_1

Strategies for epigenome analysis

A. B. Brinkman, H. G. Stunnenberg

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

7 Citations (Scopus)

Abstract

The eukaryotic genome is packaged into nucleosomes, which form the basal unit of chromatin, the physiological form of DNA within the nucleus. Apart from its function in compacting the immense nuclear DNA molecules, chromatin also serves as a platform onto which multiple signalling pathways converge to cooperate in determining the expression status of mRNAs and other (non-coding) RNA molecules. Epigenetic profile analysis aims to determine what changes on the nucleosomes cooperate to establish and maintain DNA sequence-independent heritable traits such as those determining cell identity.

Original language	English
Title of host publication	Epigenomics
Publisher	Springer Netherlands
Pages	3-18
Number of pages	16
ISBN (Electronic)	9781402091872
ISBN (Print)	9781402091865
DOIs	https://doi.org/10.1007/978-1-4020-9187-2_1
Publication status	Published - 2009
Externally published	Yes

Keywords

ChIP-on-chip
ChIP-seq
DNA methylation
Histone modifications
Profiling

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10.1007/978-1-4020-9187-2_1

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AB - The eukaryotic genome is packaged into nucleosomes, which form the basal unit of chromatin, the physiological form of DNA within the nucleus. Apart from its function in compacting the immense nuclear DNA molecules, chromatin also serves as a platform onto which multiple signalling pathways converge to cooperate in determining the expression status of mRNAs and other (non-coding) RNA molecules. Epigenetic profile analysis aims to determine what changes on the nucleosomes cooperate to establish and maintain DNA sequence-independent heritable traits such as those determining cell identity.

KW - ChIP-on-chip

KW - ChIP-seq

KW - DNA methylation

KW - Histone modifications

KW - Profiling

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SP - 3

EP - 18

BT - Epigenomics

PB - Springer Netherlands

ER -

Strategies for epigenome analysis

Abstract

Keywords

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