Structural Architecture and Functional Evolution of Wnts

J. Fernando Bazan; Claudia Y. Janda; K. Christopher Garcia

doi:10.1016/j.devcel.2012.07.011

Structural Architecture and Functional Evolution of Wnts

J. Fernando Bazan
, Claudia Y. Janda
, K. Christopher Garcia

Research output: Contribution to journal › Comment/debate

46 Citations (Scopus)

Abstract

The crystal structure of a Wnt morphogen bound to its Frizzled receptor ectodomain provides insights into the evolutionary provenance of this complex fold and offers an explanation for why Wnts utilize both lipid- and protein-mediated contacts to engage Frizzleds.

Original language	English
Pages (from-to)	227-232
Number of pages	6
Journal	Developmental Cell
Volume	23
Issue number	2
DOIs	https://doi.org/10.1016/j.devcel.2012.07.011
Publication status	Published - 14 Aug 2012
Externally published	Yes

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title = "Structural Architecture and Functional Evolution of Wnts",

abstract = "The crystal structure of a Wnt morphogen bound to its Frizzled receptor ectodomain provides insights into the evolutionary provenance of this complex fold and offers an explanation for why Wnts utilize both lipid- and protein-mediated contacts to engage Frizzleds.",

author = "Bazan, \{J. Fernando\} and Janda, \{Claudia Y.\} and Garcia, \{K. Christopher\}",

note = "Funding Information: We thank the reviewers for constructive comments that greatly improved our manuscript. We acknowledge support from HHMI and NIH RO1-GM097015 to K.C.G. and from a Jane Coffin Childs Postdoctoral Fellowship to C.Y.J.; J.F.B. is a visiting scientist in the Garcia lab. ",

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AU - Bazan, J. Fernando

AU - Janda, Claudia Y.

AU - Garcia, K. Christopher

N1 - Funding Information: We thank the reviewers for constructive comments that greatly improved our manuscript. We acknowledge support from HHMI and NIH RO1-GM097015 to K.C.G. and from a Jane Coffin Childs Postdoctoral Fellowship to C.Y.J.; J.F.B. is a visiting scientist in the Garcia lab.

PY - 2012/8/14

Y1 - 2012/8/14

N2 - The crystal structure of a Wnt morphogen bound to its Frizzled receptor ectodomain provides insights into the evolutionary provenance of this complex fold and offers an explanation for why Wnts utilize both lipid- and protein-mediated contacts to engage Frizzleds.

AB - The crystal structure of a Wnt morphogen bound to its Frizzled receptor ectodomain provides insights into the evolutionary provenance of this complex fold and offers an explanation for why Wnts utilize both lipid- and protein-mediated contacts to engage Frizzleds.

UR - https://www.scopus.com/pages/publications/84865073858

U2 - 10.1016/j.devcel.2012.07.011

DO - 10.1016/j.devcel.2012.07.011

M3 - Comment/debate

SN - 1534-5807

VL - 23

SP - 227

EP - 232

JO - Developmental Cell

JF - Developmental Cell

IS - 2

ER -

Structural Architecture and Functional Evolution of Wnts

Abstract

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