Surgical treatment of childhood hepatoblastoma in the Netherlands (1990-2013)

Linde A D Busweiler, Marc H W A Wijnen, Jim C H Wilde, Egbert Sieders, Sheila E J Terwisscha van Scheltinga, L W Ernest van Heurn, Joseph Ziros, Roel Bakx, Hugo A Heij

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


BACKGROUND: Achievement of complete surgical resection plays a key role in the successful treatment of children with hepatoblastoma. The aim of this study is to assess the surgical outcomes after partial liver resections for hepatoblastoma, focusing on postoperative complications, resection margins, 30-day mortality, and long-term survival.

METHOD: Chart reviews were carried out on all patients treated for hepatoblastoma in the Netherlands between 1990 and 2013.

RESULTS: A total of 103 patients were included, of whom 94 underwent surgery. Partial hepatectomy was performed in 76 patients and 18 patients received a liver transplant as a primary procedure. In 42 of 73 (58 %) patients, one or more complications were reported. In 3 patients, information regarding complications was not available. Hemorrhage necessitating blood transfusion occurred in 33 (45 %) patients and 9 (12 %) patients developed biliary complications, of whom 8 needed one or more additional surgical interventions. Overall, 5-year disease-specific survival was 82, 92 % in the group of patients who underwent partial hepatectomy, and 77 % in the group of patients who underwent liver transplantation.

CONCLUSIONS: Partial hepatectomy after chemotherapy in children with hepatoblastoma offers good chances of survival. This type of major surgery is associated with a high rate of surgical complications (58 %), which is not detrimental to survival.

Original languageEnglish
Pages (from-to)23-31
Number of pages9
JournalPediatric surgery international
Issue number1
Publication statusPublished - Oct 2016
Externally publishedYes


  • Biopsy
  • Child, Preschool
  • Female
  • Hepatectomy/methods
  • Hepatoblastoma/diagnosis
  • Humans
  • Incidence
  • Infant
  • Infant, Newborn
  • Liver/diagnostic imaging
  • Liver Neoplasms/diagnosis
  • Liver Transplantation/methods
  • Male
  • Margins of Excision
  • Netherlands/epidemiology
  • Survival Rate/trends
  • Treatment Outcome
  • Ultrasonography


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