Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody

Gerben Vader, Jos J W Kauw, René H Medema, Susanne M A Lens

Research output: Contribution to journalArticlepeer-review


The chromosomal passenger complex (CPC) coordinates chromosomal and cytoskeletal events of mitosis. The enzymatic core of this complex (Aurora-B) is guided through the mitotic cell by its companion chromosomal passenger proteins, inner centromere protein (INCENP), Survivin and Borealin/Dasra-B, thereby allowing it to act at the right place at the right time. Here, we addressed the individual contributions of INCENP, Survivin and Borealin to the proper functioning of this complex. We show that INCENP has an important role in stabilizing the complex, and that Borealin acts to promote binding of Survivin to INCENP. Importantly, when Survivin is directly fused to INCENP, this hybrid can restore CPC function at the centromeres and midbody, even in the absence of Borealin and the centromere-targeting domain of INCENP. Thus, Survivin is an important mediator of centromere and midbody docking of Aurora-B during mitosis.

Original languageEnglish
Pages (from-to)85-92
Number of pages8
JournalEMBO Reports
Issue number1
Publication statusPublished - Jan 2006
Externally publishedYes


  • Animals
  • Cell Cycle Proteins/genetics
  • Cell Line
  • Centromere/metabolism
  • Chromosomal Proteins, Non-Histone/genetics
  • Cysteine Proteinase Inhibitors/genetics
  • Humans
  • Inhibitor of Apoptosis Proteins
  • Macromolecular Substances
  • Microtubule-Associated Proteins/genetics
  • Mitosis
  • Neoplasm Proteins/genetics
  • Protein Binding
  • RNA Interference
  • RNA, Small Interfering/genetics
  • Recombinant Fusion Proteins/genetics
  • Survivin


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