Systemic signature of the lung response to respiratory syncytial virus infection

Jeroen L.A. Pennings, Annemieke Schuurhof, Hennie M. Hodemaekers, Annemarie Buisman, Lia C.G.H. de Rond, Myra N. Widjojoatmodjo, Willem Luytjes, Jan L.L. Kimpen, Louis Bont, Riny Janssen

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Respiratory Syncytial Virus is a frequent cause of severe bronchiolitis in children. To improve our understanding of systemic host responses to RSV, we compared BALB/c mouse gene expression responses at day 1, 2, and 5 during primary RSV infection in lung, bronchial lymph nodes, and blood. We identified a set of 53 interferon-associated and innate immunity genes that give correlated responses in all three murine tissues. Additionally, we identified blood gene signatures that are indicative of acute infection, secondary immune response, and vaccine-enhanced disease, respectively. Eosinophil-associated ribonucleases were characteristic for the vaccine-enhanced disease blood signature. These results indicate that it may be possible to distinguish protective and unfavorable patient lung responses via blood diagnostics.

Original languageEnglish
Article numbere21461
JournalPLoS ONE
Issue number6
Publication statusPublished - 2011
Externally publishedYes


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