T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation

Ya Yuan Fu; Anastasiya Egorova; Catherine Sobieski; Jason Kuttiyara; Marco Calafiore; Shuichiro Takashima; Hans Clevers; Alan M. Hanash

doi:10.1016/j.immuni.2019.06.003

T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation

Ya Yuan Fu
, Anastasiya Egorova
, Catherine Sobieski
, Jason Kuttiyara
, Marco Calafiore
, Shuichiro Takashima
, Hans Clevers
, Alan M. Hanash

Research output: Contribution to journal › Article › peer-review

87 Citations (Scopus)

Abstract

The key sites within the gastrointestinal tract where T cells mediate effector responses and their impact on intestinal stem cells remain unclear. Using 3D microscopy, Fu et al. visualize T cell spatial localization within the gastrointestinal tract, revealing the stem cell compartment as the primary intestinal target of allogeneic T cells during immune-mediated tissue damage occurring after bone marrow transplantation.

Original language	English
Pages (from-to)	90-103.e3
Journal	Immunity
Volume	51
Issue number	1
DOIs	https://doi.org/10.1016/j.immuni.2019.06.003
Publication status	Published - 16 Jul 2019
Externally published	Yes

Keywords

BMT
GVHD
ISCs
LPAM
MAdCAM-1
Paneth cells
allogeneic bone marrow transplantation
beta7 integrin
graft versus host disease
imaging of immunity
intestinal stem cells
mucosal immunology
transplantation

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10.1016/j.immuni.2019.06.003

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title = "T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation",

abstract = "The key sites within the gastrointestinal tract where T cells mediate effector responses and their impact on intestinal stem cells remain unclear. Using 3D microscopy, Fu et al. visualize T cell spatial localization within the gastrointestinal tract, revealing the stem cell compartment as the primary intestinal target of allogeneic T cells during immune-mediated tissue damage occurring after bone marrow transplantation.",

keywords = "BMT, GVHD, ISCs, LPAM, MAdCAM-1, Paneth cells, allogeneic bone marrow transplantation, beta7 integrin, graft versus host disease, imaging of immunity, intestinal stem cells, mucosal immunology, transplantation",

author = "Fu, \{Ya Yuan\} and Anastasiya Egorova and Catherine Sobieski and Jason Kuttiyara and Marco Calafiore and Shuichiro Takashima and Hans Clevers and Hanash, \{Alan M.\}",

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doi = "10.1016/j.immuni.2019.06.003",

language = "English",

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T1 - T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation

AU - Fu, Ya Yuan

AU - Egorova, Anastasiya

AU - Sobieski, Catherine

AU - Kuttiyara, Jason

AU - Calafiore, Marco

AU - Takashima, Shuichiro

AU - Clevers, Hans

AU - Hanash, Alan M.

PY - 2019/7/16

Y1 - 2019/7/16

N2 - The key sites within the gastrointestinal tract where T cells mediate effector responses and their impact on intestinal stem cells remain unclear. Using 3D microscopy, Fu et al. visualize T cell spatial localization within the gastrointestinal tract, revealing the stem cell compartment as the primary intestinal target of allogeneic T cells during immune-mediated tissue damage occurring after bone marrow transplantation.

AB - The key sites within the gastrointestinal tract where T cells mediate effector responses and their impact on intestinal stem cells remain unclear. Using 3D microscopy, Fu et al. visualize T cell spatial localization within the gastrointestinal tract, revealing the stem cell compartment as the primary intestinal target of allogeneic T cells during immune-mediated tissue damage occurring after bone marrow transplantation.

KW - BMT

KW - GVHD

KW - ISCs

KW - LPAM

KW - MAdCAM-1

KW - Paneth cells

KW - allogeneic bone marrow transplantation

KW - beta7 integrin

KW - graft versus host disease

KW - imaging of immunity

KW - intestinal stem cells

KW - mucosal immunology

KW - transplantation

UR - https://www.scopus.com/pages/publications/85068662217

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DO - 10.1016/j.immuni.2019.06.003

M3 - Article

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AN - SCOPUS:85068662217

SN - 1074-7613

VL - 51

SP - 90-103.e3

JO - Immunity

JF - Immunity

IS - 1

ER -

T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation

Abstract

Keywords

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