T cells in B cell chronic lymphocytic leukaemia. I. Decreased frequency of T lymphocytes secreting suppressor factor

A. C. Bloem; J. C. Clevers; E. J.E.G. Bast; R. E. Ballieux

T cells in B cell chronic lymphocytic leukaemia. I. Decreased frequency of T lymphocytes secreting suppressor factor

A. C. Bloem
, J. C. Clevers
, E. J.E.G. Bast
, R. E. Ballieux

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

A reverse T cell plaque assay was employed to study the ability of purified T cells isolated from the blood of seven patients with B cell chronic lymphocytic leukaemia (B-CLL) to secrete antigen-specific helper or suppressor factors (ThF and TsF respectively) after activation in vitro. It was found that in spite of the phenotypical presence of CD8⁺ cells, the frequency of TsF-secreting cells was strongly decreased as compared to normal values. T cells secreting ThF could be generated in all B-CLL patients tested in about normal frequencies. These results may indicate a tumour induced change in the distribution of cellular subsets within the CD8⁺ cell compartment.

Original language	English
Pages (from-to)	188-193
Number of pages	6
Journal	Clinical and Experimental Immunology
Volume	63
Issue number	1
Publication status	Published - 1986
Externally published	Yes

Cite this

@article{652e54231d0a40c68a6a668499073f62,

title = "T cells in B cell chronic lymphocytic leukaemia. I. Decreased frequency of T lymphocytes secreting suppressor factor",

abstract = "A reverse T cell plaque assay was employed to study the ability of purified T cells isolated from the blood of seven patients with B cell chronic lymphocytic leukaemia (B-CLL) to secrete antigen-specific helper or suppressor factors (ThF and TsF respectively) after activation in vitro. It was found that in spite of the phenotypical presence of CD8+ cells, the frequency of TsF-secreting cells was strongly decreased as compared to normal values. T cells secreting ThF could be generated in all B-CLL patients tested in about normal frequencies. These results may indicate a tumour induced change in the distribution of cellular subsets within the CD8+ cell compartment.",

author = "Bloem, \{A. C.\} and Clevers, \{J. C.\} and Bast, \{E. J.E.G.\} and Ballieux, \{R. E.\}",

year = "1986",

language = "English",

volume = "63",

pages = "188--193",

journal = "Clinical and Experimental Immunology",

issn = "0009-9104",

publisher = "Oxford University Press",

number = "1",

}

TY - JOUR

T1 - T cells in B cell chronic lymphocytic leukaemia. I. Decreased frequency of T lymphocytes secreting suppressor factor

AU - Bloem, A. C.

AU - Clevers, J. C.

AU - Bast, E. J.E.G.

AU - Ballieux, R. E.

PY - 1986

Y1 - 1986

N2 - A reverse T cell plaque assay was employed to study the ability of purified T cells isolated from the blood of seven patients with B cell chronic lymphocytic leukaemia (B-CLL) to secrete antigen-specific helper or suppressor factors (ThF and TsF respectively) after activation in vitro. It was found that in spite of the phenotypical presence of CD8+ cells, the frequency of TsF-secreting cells was strongly decreased as compared to normal values. T cells secreting ThF could be generated in all B-CLL patients tested in about normal frequencies. These results may indicate a tumour induced change in the distribution of cellular subsets within the CD8+ cell compartment.

AB - A reverse T cell plaque assay was employed to study the ability of purified T cells isolated from the blood of seven patients with B cell chronic lymphocytic leukaemia (B-CLL) to secrete antigen-specific helper or suppressor factors (ThF and TsF respectively) after activation in vitro. It was found that in spite of the phenotypical presence of CD8+ cells, the frequency of TsF-secreting cells was strongly decreased as compared to normal values. T cells secreting ThF could be generated in all B-CLL patients tested in about normal frequencies. These results may indicate a tumour induced change in the distribution of cellular subsets within the CD8+ cell compartment.

UR - https://www.scopus.com/pages/publications/0022643421

M3 - Article

C2 - 3485483

AN - SCOPUS:0022643421

SN - 0009-9104

VL - 63

SP - 188

EP - 193

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

IS - 1

ER -

T cells in B cell chronic lymphocytic leukaemia. I. Decreased frequency of T lymphocytes secreting suppressor factor

Abstract

Fingerprint

Cite this