Targeting the tumor microenvironment: Removing obstruction to anticancer immune responses and immunotherapy

J. M. Pitt; A. Marabelle; A. Eggermont; J. C. Soria; G. Kroemer; Laurence Zitvogel

doi:10.1093/annonc/mdw168

Targeting the tumor microenvironment: Removing obstruction to anticancer immune responses and immunotherapy

J. M. Pitt, A. Marabelle, A. Eggermont, J. C. Soria, G. Kroemer, Laurence Zitvogel

Research output: Contribution to journal › Review article › peer-review

817 Citations (Scopus)

Abstract

The tumor microenvironment (TME) is an integral part of cancer. Recognition of the essential nature of the TME in cancer evolution has led to a shift from a tumor cell-centered view of cancer development to the concept of a complex tumor ecosystem that supports tumor growth and metastatic dissemination. Accordingly, novel targets within the TME have been uncovered that can help direct and improve the actions of various cancer therapies, notably immunotherapies that work by potentiating host antitumor immune responses. Here, we review the composition of the TME, how this attenuates immunosurveillance, and discuss existing and potential strategies aimed at targeting cellular and molecular TME components.

Original language	English
Pages (from-to)	1482-1492
Number of pages	11
Journal	Annals of Oncology
Volume	27
Issue number	8
DOIs	https://doi.org/10.1093/annonc/mdw168
Publication status	Published - 1 Aug 2016
Externally published	Yes

Keywords

Angiogenesis
Anticancer therapy
Cancer
Immunosuppression
Immunotherapy
Tumor microenvironment

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abstract = "The tumor microenvironment (TME) is an integral part of cancer. Recognition of the essential nature of the TME in cancer evolution has led to a shift from a tumor cell-centered view of cancer development to the concept of a complex tumor ecosystem that supports tumor growth and metastatic dissemination. Accordingly, novel targets within the TME have been uncovered that can help direct and improve the actions of various cancer therapies, notably immunotherapies that work by potentiating host antitumor immune responses. Here, we review the composition of the TME, how this attenuates immunosurveillance, and discuss existing and potential strategies aimed at targeting cellular and molecular TME components.",

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AU - Pitt, J. M.

AU - Marabelle, A.

AU - Eggermont, A.

AU - Soria, J. C.

AU - Kroemer, G.

AU - Zitvogel, Laurence

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AB - The tumor microenvironment (TME) is an integral part of cancer. Recognition of the essential nature of the TME in cancer evolution has led to a shift from a tumor cell-centered view of cancer development to the concept of a complex tumor ecosystem that supports tumor growth and metastatic dissemination. Accordingly, novel targets within the TME have been uncovered that can help direct and improve the actions of various cancer therapies, notably immunotherapies that work by potentiating host antitumor immune responses. Here, we review the composition of the TME, how this attenuates immunosurveillance, and discuss existing and potential strategies aimed at targeting cellular and molecular TME components.

KW - Angiogenesis

KW - Anticancer therapy

KW - Cancer

KW - Immunosuppression

KW - Immunotherapy

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Targeting the tumor microenvironment: Removing obstruction to anticancer immune responses and immunotherapy

Abstract

Keywords

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