TY - JOUR
T1 - TCF and Groucho-Related Genes Influence Pituitary Growth and Development
AU - Brinkmeier, Michelle L.
AU - Potok, Mary Anne
AU - Cha, Kelly B.
AU - Gridley, Thomas
AU - Stifani, Stefano
AU - Meeldijk, Jan
AU - Clevers, Hans
AU - Camper, Sally A.
PY - 2003/11
Y1 - 2003/11
N2 - Mutations in the prophet of PIT1 gene (PROP1) are the most common cause of multiple pituitary hormone deficiency in humans; however, the mechanism of PROP1 action is not well understood. We report that Prop1 is essential for dorsally restricted expression of a Groucho-related gene, transducinlike enhancer of split 3 (Tte3), which encodes a transcriptional corepressor. Deficiency of a related gene, amino terminal enhancer of split (Aes), causes pituitary anomalies and growth insufficiency. TLE3 and AES have been shown to interact with TCF/LEF (transcripiton factors of the T cell-specific and lymphoid enhancer specific group) family members in cell culture systems. In the absence of TCF4 (Tcf7L2), Prop1 levels are elevated, pituitary hyperplasia ensues and palate closure is abnormal. Thus, we demonstrate that Tcf4 and Aes influence pituitary growth and development, and place Tcf4 and Tle3 in the genetic hierarchy with Prop1.
AB - Mutations in the prophet of PIT1 gene (PROP1) are the most common cause of multiple pituitary hormone deficiency in humans; however, the mechanism of PROP1 action is not well understood. We report that Prop1 is essential for dorsally restricted expression of a Groucho-related gene, transducinlike enhancer of split 3 (Tte3), which encodes a transcriptional corepressor. Deficiency of a related gene, amino terminal enhancer of split (Aes), causes pituitary anomalies and growth insufficiency. TLE3 and AES have been shown to interact with TCF/LEF (transcripiton factors of the T cell-specific and lymphoid enhancer specific group) family members in cell culture systems. In the absence of TCF4 (Tcf7L2), Prop1 levels are elevated, pituitary hyperplasia ensues and palate closure is abnormal. Thus, we demonstrate that Tcf4 and Aes influence pituitary growth and development, and place Tcf4 and Tle3 in the genetic hierarchy with Prop1.
UR - http://www.scopus.com/inward/record.url?scp=0242298721&partnerID=8YFLogxK
U2 - 10.1210/me.2003-0225
DO - 10.1210/me.2003-0225
M3 - Article
C2 - 12907761
AN - SCOPUS:0242298721
SN - 0888-8809
VL - 17
SP - 2152
EP - 2161
JO - Molecular Endocrinology
JF - Molecular Endocrinology
IS - 11
ER -