The AMORE protocol as salvage treatment for non-orbital head and neck rhabdomyosarcoma in children

J Buwalda; L E C M Blank; P F Schouwenburg; M P Copper; S D Strackee; P A Voûte; J H M Merks; H N Caron

doi:10.1016/j.ejso.2004.06.005

The AMORE protocol as salvage treatment for non-orbital head and neck rhabdomyosarcoma in children

J Buwalda, L E C M Blank, P F Schouwenburg, M P Copper, S D Strackee, P A Voûte, J H M Merks, H N Caron

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

AIM: To investigate the feasibility and outcome of the AMORE protocol as salvage treatment in paediatric head and neck rhabdomyosarcoma (HNRMS).

METHODS: The AMORE protocol is a local treatment regimen, consisting of Ablative surgery, Moulage technique brachytherapy and surgical Reconstruction, scheduled in 1 week. Patients with recurrent or residual non-orbital HNRMS were eligible for AMORE salvage treatment.

RESULTS: The procedure was feasible in nine out of 11 eligible patients. Five patients were treated for recurrent or residual parameningeal RMS after prior chemoradiation. Local complete remission was achieved in all five patients and maintained in four. Three patients are without evidence of RMS with a follow-up duration of 4-10 years. Two patients developed a distant relapse, together with a local recurrence in one. Both patients died of their disease. Four patients were included for recurrent non-parameningeal HNRMS. Long-term local control at the site of recurrence was obtained in all four patients (follow-up 5-10 years).

CONCLUSIONS: The AMORE protocol is a feasible salvage strategy for non-orbital HNRMS even after external beam radiotherapy. The local salvage rate in this series is promising.

Original language	English
Pages (from-to)	884-92
Number of pages	9
Journal	European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Volume	30
Issue number	8
DOIs	https://doi.org/10.1016/j.ejso.2004.06.005
Publication status	Published - Oct 2004
Externally published	Yes

Keywords

Brachytherapy
Child
Child, Preschool
Combined Modality Therapy
Female
Head and Neck Neoplasms/mortality
Humans
Magnetic Resonance Imaging
Male
Neck Dissection/methods
Neoplasm Staging
Netherlands
Patient Selection
Postoperative Complications
Prognosis
Radiotherapy, Adjuvant
Reconstructive Surgical Procedures/methods
Retrospective Studies
Rhabdomyosarcoma/mortality
Risk Assessment
Salvage Therapy
Sampling Studies
Survival Analysis
Tomography, X-Ray Computed
Treatment Outcome

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10.1016/j.ejso.2004.06.005

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Buwalda, J., Blank, L. E. C. M., Schouwenburg, P. F., Copper, M. P., Strackee, S. D., Voûte, P. A., Merks, J. H. M., & Caron, H. N. (2004). The AMORE protocol as salvage treatment for non-orbital head and neck rhabdomyosarcoma in children. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 30(8), 884-92. https://doi.org/10.1016/j.ejso.2004.06.005

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abstract = "AIM: To investigate the feasibility and outcome of the AMORE protocol as salvage treatment in paediatric head and neck rhabdomyosarcoma (HNRMS).METHODS: The AMORE protocol is a local treatment regimen, consisting of Ablative surgery, Moulage technique brachytherapy and surgical Reconstruction, scheduled in 1 week. Patients with recurrent or residual non-orbital HNRMS were eligible for AMORE salvage treatment.RESULTS: The procedure was feasible in nine out of 11 eligible patients. Five patients were treated for recurrent or residual parameningeal RMS after prior chemoradiation. Local complete remission was achieved in all five patients and maintained in four. Three patients are without evidence of RMS with a follow-up duration of 4-10 years. Two patients developed a distant relapse, together with a local recurrence in one. Both patients died of their disease. Four patients were included for recurrent non-parameningeal HNRMS. Long-term local control at the site of recurrence was obtained in all four patients (follow-up 5-10 years).CONCLUSIONS: The AMORE protocol is a feasible salvage strategy for non-orbital HNRMS even after external beam radiotherapy. The local salvage rate in this series is promising.",

keywords = "Brachytherapy, Child, Child, Preschool, Combined Modality Therapy, Female, Head and Neck Neoplasms/mortality, Humans, Magnetic Resonance Imaging, Male, Neck Dissection/methods, Neoplasm Staging, Netherlands, Patient Selection, Postoperative Complications, Prognosis, Radiotherapy, Adjuvant, Reconstructive Surgical Procedures/methods, Retrospective Studies, Rhabdomyosarcoma/mortality, Risk Assessment, Salvage Therapy, Sampling Studies, Survival Analysis, Tomography, X-Ray Computed, Treatment Outcome",

author = "J Buwalda and Blank, {L E C M} and Schouwenburg, {P F} and Copper, {M P} and Strackee, {S D} and Vo{\^u}te, {P A} and Merks, {J H M} and Caron, {H N}",

year = "2004",

month = oct,

doi = "10.1016/j.ejso.2004.06.005",

language = "English",

volume = "30",

pages = "884--92",

journal = "European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology",

issn = "0748-7983",

publisher = "W.B. Saunders Ltd",

number = "8",

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Buwalda, J, Blank, LECM, Schouwenburg, PF, Copper, MP, Strackee, SD, Voûte, PA, Merks, JHM & Caron, HN 2004, 'The AMORE protocol as salvage treatment for non-orbital head and neck rhabdomyosarcoma in children', European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, vol. 30, no. 8, pp. 884-92. https://doi.org/10.1016/j.ejso.2004.06.005

The AMORE protocol as salvage treatment for non-orbital head and neck rhabdomyosarcoma in children. / Buwalda, J; Blank, L E C M; Schouwenburg, P F et al.
In: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, Vol. 30, No. 8, 10.2004, p. 884-92.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The AMORE protocol as salvage treatment for non-orbital head and neck rhabdomyosarcoma in children

AU - Buwalda, J

AU - Blank, L E C M

AU - Schouwenburg, P F

AU - Copper, M P

AU - Strackee, S D

AU - Voûte, P A

AU - Merks, J H M

AU - Caron, H N

PY - 2004/10

Y1 - 2004/10

N2 - AIM: To investigate the feasibility and outcome of the AMORE protocol as salvage treatment in paediatric head and neck rhabdomyosarcoma (HNRMS).METHODS: The AMORE protocol is a local treatment regimen, consisting of Ablative surgery, Moulage technique brachytherapy and surgical Reconstruction, scheduled in 1 week. Patients with recurrent or residual non-orbital HNRMS were eligible for AMORE salvage treatment.RESULTS: The procedure was feasible in nine out of 11 eligible patients. Five patients were treated for recurrent or residual parameningeal RMS after prior chemoradiation. Local complete remission was achieved in all five patients and maintained in four. Three patients are without evidence of RMS with a follow-up duration of 4-10 years. Two patients developed a distant relapse, together with a local recurrence in one. Both patients died of their disease. Four patients were included for recurrent non-parameningeal HNRMS. Long-term local control at the site of recurrence was obtained in all four patients (follow-up 5-10 years).CONCLUSIONS: The AMORE protocol is a feasible salvage strategy for non-orbital HNRMS even after external beam radiotherapy. The local salvage rate in this series is promising.

AB - AIM: To investigate the feasibility and outcome of the AMORE protocol as salvage treatment in paediatric head and neck rhabdomyosarcoma (HNRMS).METHODS: The AMORE protocol is a local treatment regimen, consisting of Ablative surgery, Moulage technique brachytherapy and surgical Reconstruction, scheduled in 1 week. Patients with recurrent or residual non-orbital HNRMS were eligible for AMORE salvage treatment.RESULTS: The procedure was feasible in nine out of 11 eligible patients. Five patients were treated for recurrent or residual parameningeal RMS after prior chemoradiation. Local complete remission was achieved in all five patients and maintained in four. Three patients are without evidence of RMS with a follow-up duration of 4-10 years. Two patients developed a distant relapse, together with a local recurrence in one. Both patients died of their disease. Four patients were included for recurrent non-parameningeal HNRMS. Long-term local control at the site of recurrence was obtained in all four patients (follow-up 5-10 years).CONCLUSIONS: The AMORE protocol is a feasible salvage strategy for non-orbital HNRMS even after external beam radiotherapy. The local salvage rate in this series is promising.

KW - Brachytherapy

KW - Child

KW - Child, Preschool

KW - Combined Modality Therapy

KW - Female

KW - Head and Neck Neoplasms/mortality

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Neck Dissection/methods

KW - Neoplasm Staging

KW - Netherlands

KW - Patient Selection

KW - Postoperative Complications

KW - Prognosis

KW - Radiotherapy, Adjuvant

KW - Reconstructive Surgical Procedures/methods

KW - Retrospective Studies

KW - Rhabdomyosarcoma/mortality

KW - Risk Assessment

KW - Salvage Therapy

KW - Sampling Studies

KW - Survival Analysis

KW - Tomography, X-Ray Computed

KW - Treatment Outcome

U2 - 10.1016/j.ejso.2004.06.005

DO - 10.1016/j.ejso.2004.06.005

M3 - Article

C2 - 15336736

SN - 0748-7983

VL - 30

SP - 884

EP - 892

JO - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

JF - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

IS - 8

ER -

Buwalda J, Blank LECM, Schouwenburg PF, Copper MP, Strackee SD, Voûte PA et al. The AMORE protocol as salvage treatment for non-orbital head and neck rhabdomyosarcoma in children. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 2004 Oct;30(8):884-92. doi: 10.1016/j.ejso.2004.06.005

The AMORE protocol as salvage treatment for non-orbital head and neck rhabdomyosarcoma in children

Abstract

Keywords

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