The boosting of didanosine by allopurinol permits a halving of the didanosine dosage

Johan R. Boelaert; Geneviève M. Dom; Alwin D.R. Huitema; Jos H. Beijnen; Joep M.A. Lange

doi:10.1097/00002030-200211080-00016

The boosting of didanosine by allopurinol permits a halving of the didanosine dosage

Johan R. Boelaert, Geneviève M. Dom, Alwin D.R. Huitema, Jos H. Beijnen, Joep M.A. Lange

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The pharmacokinetic boosting of didanosine by allopurinol was studied in four HIV-1-positive patients taking didanosine, hydroxyurea and chloroquine, in whom the didanosine dosage was halved and allopurinol was added at 300 mg/day. Didanosine plasma levels and HIV-1-RNA levels remained unchanged after 4 and 17-20 months, respectively. Halving the didanosine dosage with allopurinol reduces treatment costs, and may lend itself to once-daily combination therapies, which are of particular interest for HIV therapy in resource-poor countries.

Original language	English
Pages (from-to)	2221-2223
Number of pages	3
Journal	AIDS
Volume	16
Issue number	16
DOIs	https://doi.org/10.1097/00002030-200211080-00016
Publication status	Published - 8 Nov 2002
Externally published	Yes

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title = "The boosting of didanosine by allopurinol permits a halving of the didanosine dosage",

abstract = "The pharmacokinetic boosting of didanosine by allopurinol was studied in four HIV-1-positive patients taking didanosine, hydroxyurea and chloroquine, in whom the didanosine dosage was halved and allopurinol was added at 300 mg/day. Didanosine plasma levels and HIV-1-RNA levels remained unchanged after 4 and 17-20 months, respectively. Halving the didanosine dosage with allopurinol reduces treatment costs, and may lend itself to once-daily combination therapies, which are of particular interest for HIV therapy in resource-poor countries.",

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T1 - The boosting of didanosine by allopurinol permits a halving of the didanosine dosage

AU - Boelaert, Johan R.

AU - Dom, Geneviève M.

AU - Huitema, Alwin D.R.

AU - Beijnen, Jos H.

AU - Lange, Joep M.A.

PY - 2002/11/8

Y1 - 2002/11/8

N2 - The pharmacokinetic boosting of didanosine by allopurinol was studied in four HIV-1-positive patients taking didanosine, hydroxyurea and chloroquine, in whom the didanosine dosage was halved and allopurinol was added at 300 mg/day. Didanosine plasma levels and HIV-1-RNA levels remained unchanged after 4 and 17-20 months, respectively. Halving the didanosine dosage with allopurinol reduces treatment costs, and may lend itself to once-daily combination therapies, which are of particular interest for HIV therapy in resource-poor countries.

AB - The pharmacokinetic boosting of didanosine by allopurinol was studied in four HIV-1-positive patients taking didanosine, hydroxyurea and chloroquine, in whom the didanosine dosage was halved and allopurinol was added at 300 mg/day. Didanosine plasma levels and HIV-1-RNA levels remained unchanged after 4 and 17-20 months, respectively. Halving the didanosine dosage with allopurinol reduces treatment costs, and may lend itself to once-daily combination therapies, which are of particular interest for HIV therapy in resource-poor countries.

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VL - 16

SP - 2221

EP - 2223

JO - AIDS

JF - AIDS

IS - 16

ER -

The boosting of didanosine by allopurinol permits a halving of the didanosine dosage

Abstract

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