The challenge to bring personalized cancer medicine from clinical trials into routine clinical practice: The case of the Institut Gustave Roussy

Monica Arnedos, Fabrice André, Françoise Farace, Ludovic Lacroix, Benjamin Besse, Caroline Robert, Jean Charles Soria, Alexander M.M. Eggermont

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)

Abstract

Research with high throughput technologies has propitiated the segmentation of different types of tumors into very small subgroups characterized by the presence of very rare molecular alterations.The identification of these subgroups and the apparition of new agents targeting these infrequent alterations are already affecting the way in which clinical trials are being conducted with an increased need to identify those patients harboring specific molecular alterations.In this review we describe some of the currently ongoing and future studies at the Institut Gustave Roussy that aim for the identification of potential therapeutic targets for cancer patients with the incorporation of high throughput technologies into daily practice including aCGH, next generation sequencing and the creation of a software that allows for target identification specific for each tumor. The initial intention is to enrich clinical trials with cancer patients carrying certain molecular alterations in order to increase the possibility of demonstrating benefit from a targeted agent. Mid and long term aims are to facilitate and speed up the process of drug development as well as to implement the concept of personalized medicine.

Original languageEnglish
Pages (from-to)204-210
Number of pages7
JournalMolecular Oncology
Volume6
Issue number2
DOIs
Publication statusPublished - Apr 2012
Externally publishedYes

Keywords

  • High throughput technologies
  • Metastatic cancer
  • Personalized medicine
  • Translational research

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