The clinical pharmacology of alkylating agents in high-dose chemotherapy

Alwin D.R. Huitema; Karen Doesburg Smits; Ron A.A. Mathôt; Jan H.M. Schellens; Sjoerd Rodenhuis; Jos H. Beijnen

doi:10.1097/00001813-200008000-00002

The clinical pharmacology of alkylating agents in high-dose chemotherapy

Alwin D.R. Huitema
, Karen Doesburg Smits
, Ron A.A. Mathôt
, Jan H.M. Schellens
, Sjoerd Rodenhuis
, Jos H. Beijnen

Research output: Contribution to journal › Review article › peer-review

42 Citations (Scopus)

Abstract

Alkylating agents are widely used in high-dose chemotherapy regimens in combination with hematological support. Knowledge about the pharmacokinetics and pharmacodynamics of these agents administered in high doses is critical for the safe and efficient use of these regimens. The aim of this review is to summarize the clinical pharmacology of the alkylating agents (including the platinum compounds) in high-dose chemotherapy. Differences between conventional and high doses will be discussed. (C) 2000 Lippincott Williams and Wilkins.

Original language	English
Pages (from-to)	515-533
Number of pages	19
Journal	Anti-Cancer Drugs
Volume	11
Issue number	7
DOIs	https://doi.org/10.1097/00001813-200008000-00002
Publication status	Published - 2000
Externally published	Yes

Keywords

Alkylating agents
Clinical pharmacology
High-dose chemotherapy

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10.1097/00001813-200008000-00002

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title = "The clinical pharmacology of alkylating agents in high-dose chemotherapy",

abstract = "Alkylating agents are widely used in high-dose chemotherapy regimens in combination with hematological support. Knowledge about the pharmacokinetics and pharmacodynamics of these agents administered in high doses is critical for the safe and efficient use of these regimens. The aim of this review is to summarize the clinical pharmacology of the alkylating agents (including the platinum compounds) in high-dose chemotherapy. Differences between conventional and high doses will be discussed. (C) 2000 Lippincott Williams and Wilkins.",

keywords = "Alkylating agents, Clinical pharmacology, High-dose chemotherapy",

author = "Huitema, \{Alwin D.R.\} and Smits, \{Karen Doesburg\} and Math{\^o}t, \{Ron A.A.\} and Schellens, \{Jan H.M.\} and Sjoerd Rodenhuis and Beijnen, \{Jos H.\}",

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T1 - The clinical pharmacology of alkylating agents in high-dose chemotherapy

AU - Huitema, Alwin D.R.

AU - Smits, Karen Doesburg

AU - Mathôt, Ron A.A.

AU - Schellens, Jan H.M.

AU - Rodenhuis, Sjoerd

AU - Beijnen, Jos H.

PY - 2000

Y1 - 2000

N2 - Alkylating agents are widely used in high-dose chemotherapy regimens in combination with hematological support. Knowledge about the pharmacokinetics and pharmacodynamics of these agents administered in high doses is critical for the safe and efficient use of these regimens. The aim of this review is to summarize the clinical pharmacology of the alkylating agents (including the platinum compounds) in high-dose chemotherapy. Differences between conventional and high doses will be discussed. (C) 2000 Lippincott Williams and Wilkins.

AB - Alkylating agents are widely used in high-dose chemotherapy regimens in combination with hematological support. Knowledge about the pharmacokinetics and pharmacodynamics of these agents administered in high doses is critical for the safe and efficient use of these regimens. The aim of this review is to summarize the clinical pharmacology of the alkylating agents (including the platinum compounds) in high-dose chemotherapy. Differences between conventional and high doses will be discussed. (C) 2000 Lippincott Williams and Wilkins.

KW - Alkylating agents

KW - Clinical pharmacology

KW - High-dose chemotherapy

UR - https://www.scopus.com/pages/publications/0033800062

U2 - 10.1097/00001813-200008000-00002

DO - 10.1097/00001813-200008000-00002

M3 - Review article

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AN - SCOPUS:0033800062

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VL - 11

SP - 515

EP - 533

JO - Anti-Cancer Drugs

JF - Anti-Cancer Drugs

IS - 7

ER -

The clinical pharmacology of alkylating agents in high-dose chemotherapy

Abstract

Keywords

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