The drug resistance-related protein LRP is the human major vault protein

George L. Scheffer; Peter L.J. Wijngaard; Marcel J. Flens; Miguel A. Izquierdo; Marilyn L. Slovak; Herbert M. Pinedo; Chris J.L.M. Meijer; Hans C. Clevers; Rik J. Scheper

doi:10.1038/nm0695-578

The drug resistance-related protein LRP is the human major vault protein

George L. Scheffer
, Peter L.J. Wijngaard
, Marcel J. Flens
, Miguel A. Izquierdo
, Marilyn L. Slovak
, Herbert M. Pinedo
, Chris J.L.M. Meijer
, Hans C. Clevers
, Rik J. Scheper

Research output: Contribution to journal › Article › peer-review

606 Citations (Scopus)

Abstract

Multidrug-resistant cancer cells frequently overexpress the 110-kD LRP protein (originally named Lung Resistance-related Protein). LRP overexpression has been found to predict a poor response to chemotherapy in acute myeloid leukaemia and ovarian carcinoma. We describe the cloning and chromosome localization of the gene coding for this novel protein. The deduced LRP amino acid sequence shows 87.7% identity with the 104-kD rat major vault protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. The LRP gene is located on chromosome 16, close to the genes coding for multidrug resistance-associated protein and protein kinase C-β, and may mediate drug resistance, perhaps via a transport process.

Original language	English
Pages (from-to)	578-582
Number of pages	5
Journal	Nature medicine
Volume	1
Issue number	6
DOIs	https://doi.org/10.1038/nm0695-578
Publication status	Published - Jun 1995
Externally published	Yes

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title = "The drug resistance-related protein LRP is the human major vault protein",

abstract = "Multidrug-resistant cancer cells frequently overexpress the 110-kD LRP protein (originally named Lung Resistance-related Protein). LRP overexpression has been found to predict a poor response to chemotherapy in acute myeloid leukaemia and ovarian carcinoma. We describe the cloning and chromosome localization of the gene coding for this novel protein. The deduced LRP amino acid sequence shows 87.7\% identity with the 104-kD rat major vault protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. The LRP gene is located on chromosome 16, close to the genes coding for multidrug resistance-associated protein and protein kinase C-β, and may mediate drug resistance, perhaps via a transport process.",

author = "Scheffer, \{George L.\} and Wijngaard, \{Peter L.J.\} and Flens, \{Marcel J.\} and Izquierdo, \{Miguel A.\} and Slovak, \{Marilyn L.\} and Pinedo, \{Herbert M.\} and Meijer, \{Chris J.L.M.\} and Clevers, \{Hans C.\} and Scheper, \{Rik J.\}",

year = "1995",

month = jun,

doi = "10.1038/nm0695-578",

language = "English",

volume = "1",

pages = "578--582",

journal = "Nature medicine",

issn = "1078-8956",

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TY - JOUR

T1 - The drug resistance-related protein LRP is the human major vault protein

AU - Scheffer, George L.

AU - Wijngaard, Peter L.J.

AU - Flens, Marcel J.

AU - Izquierdo, Miguel A.

AU - Slovak, Marilyn L.

AU - Pinedo, Herbert M.

AU - Meijer, Chris J.L.M.

AU - Clevers, Hans C.

AU - Scheper, Rik J.

PY - 1995/6

Y1 - 1995/6

N2 - Multidrug-resistant cancer cells frequently overexpress the 110-kD LRP protein (originally named Lung Resistance-related Protein). LRP overexpression has been found to predict a poor response to chemotherapy in acute myeloid leukaemia and ovarian carcinoma. We describe the cloning and chromosome localization of the gene coding for this novel protein. The deduced LRP amino acid sequence shows 87.7% identity with the 104-kD rat major vault protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. The LRP gene is located on chromosome 16, close to the genes coding for multidrug resistance-associated protein and protein kinase C-β, and may mediate drug resistance, perhaps via a transport process.

AB - Multidrug-resistant cancer cells frequently overexpress the 110-kD LRP protein (originally named Lung Resistance-related Protein). LRP overexpression has been found to predict a poor response to chemotherapy in acute myeloid leukaemia and ovarian carcinoma. We describe the cloning and chromosome localization of the gene coding for this novel protein. The deduced LRP amino acid sequence shows 87.7% identity with the 104-kD rat major vault protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. The LRP gene is located on chromosome 16, close to the genes coding for multidrug resistance-associated protein and protein kinase C-β, and may mediate drug resistance, perhaps via a transport process.

UR - https://www.scopus.com/pages/publications/0029048485

U2 - 10.1038/nm0695-578

DO - 10.1038/nm0695-578

M3 - Article

C2 - 7585126

AN - SCOPUS:0029048485

SN - 1078-8956

VL - 1

SP - 578

EP - 582

JO - Nature medicine

JF - Nature medicine

IS - 6

ER -

The drug resistance-related protein LRP is the human major vault protein

Abstract

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