The emerging era of targeted therapy in childhood acute lymphoblastic leukemia

William L. Carroll, Rob Pieters

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Citations (Scopus)


One of the most fundamental goals of modern cancer research is to develop more effective therapies that specifically target the cancer cell while sparing normal cells from the collateral damage that is common to conventional therapies. The cornerstone of current cancer treatment depends on drugs associated with a very narrow therapeutic index in that the effective dose and the toxic dose frequently overlap. While progress in pediatric oncology, specifically, improved cure rates for the most common childhood malignancy, acute lymphoblastic leukemia (ALL), has outpaced improvements in other cancer subtypes, treatment for ALL still relies on conventional cytotoxic agents thereby exposing children to considerable short- and long-term side effects.

Original languageEnglish
Title of host publicationMolecularly Targeted Therapy for Childhood Cancer
PublisherSpringer New York
Number of pages16
ISBN (Print)9780387690605
Publication statusPublished - 2010
Externally publishedYes


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