The expanding clinical phenotype of germline ABL1-associated congenital heart defects and skeletal malformations syndrome

Chun An Chen, Emeline Crutcher, Harinder Gill, Tanya N. Nelson, Laurie A. Robak, Marjolijn C.J. Jongmans, Rolph Pfundt, Chitra Prasad, Roberta A. Berard, Madeleine Fannemel, Eirik Frengen, Doriana Misceo, Keri Ramsey, Yaping Yang, Christian P. Schaaf, Xia Wang

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Congenital heart defects and skeletal malformations syndrome (CHDSKM) is a rare autosomal dominant disorder characterized by congenital heart disease, skeletal abnormalities, and failure to thrive. CHDSKM is caused by germline mutations in ABL1. To date, three variants have been in association with CHDSKM. In this study, we describe three de novo missense variants, c.407C'T (p.Thr136Met), c.746C'T (p.Pro249Leu), and c.1573G'A (p.Val525Met), and one recurrent variant, c.1066G'A (p.Ala356Thr), in six patients, thereby expanding the phenotypic spectrum of CHDSKM to include hearing impairment, lipodystrophy-like features, renal hypoplasia, and distinct ocular abnormalities. Functional investigation of the three novel variants showed an increased ABL1 kinase activity. The cardiac findings in additional patients with p.Ala356Thr contribute to the accumulating evidence that patients carrying either one of the recurrent variants, p.Tyr245Cys and p.Ala356Thr, have a high incidence of cardiac abnormalities. The phenotypic expansion has implications for the clinical diagnosis of CHDSKM in patients with germline ABL1 variants.

Original languageEnglish
Pages (from-to)1738-1744
Number of pages7
JournalHuman Mutation
Volume41
Issue number10
DOIs
Publication statusPublished - 1 Oct 2020
Externally publishedYes

Keywords

  • CHDSKM
  • congenital heart defects
  • hearing impairment
  • renal hypoplasia
  • skeletal malformations

Fingerprint

Dive into the research topics of 'The expanding clinical phenotype of germline ABL1-associated congenital heart defects and skeletal malformations syndrome'. Together they form a unique fingerprint.

Cite this