The genes for variant antigens in trypanosomes

P. Borst; A. C.C. Frasch; A. Bernards; J. H. Hoeijmakers; L. H. Van der Ploeg; G. A. Cross

doi:10.4269/ajtmh.1980.29.1033

The genes for variant antigens in trypanosomes

P. Borst
, A. C.C. Frasch
, A. Bernards
, J. H. Hoeijmakers
, L. H. Van der Ploeg
, G. A. Cross

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

We have studied the mechanism of antigenic variation by using DNA complementary to the messenger RNAs for four variant surface glycoproteins of Trypansoma brucei. Pure complementary DNAs were obtained by cloning as recombinant DNA in Escherichia coli. Using these complementary DNAs as hybridization probes, we have analyzed the genes for these variant surface glycoproteins. The results provide new information on the origin and evolution of antigenic variation, and on the mechanism involved in switching from one antigenic type to another.

Original language	English
Pages (from-to)	1033-1036
Number of pages	4
Journal	American Journal of Tropical Medicine and Hygiene
Volume	29
Issue number	5 II
DOIs	https://doi.org/10.4269/ajtmh.1980.29.1033
Publication status	Published - 1980
Externally published	Yes

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10.4269/ajtmh.1980.29.1033

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AU - Frasch, A. C.C.

AU - Bernards, A.

AU - Hoeijmakers, J. H.

AU - Van der Ploeg, L. H.

AU - Cross, G. A.

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AB - We have studied the mechanism of antigenic variation by using DNA complementary to the messenger RNAs for four variant surface glycoproteins of Trypansoma brucei. Pure complementary DNAs were obtained by cloning as recombinant DNA in Escherichia coli. Using these complementary DNAs as hybridization probes, we have analyzed the genes for these variant surface glycoproteins. The results provide new information on the origin and evolution of antigenic variation, and on the mechanism involved in switching from one antigenic type to another.

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JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

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ER -

The genes for variant antigens in trypanosomes

Abstract

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