TY - JOUR
T1 - The human TRIDENT/HFH- 11/FKHL16 gene
T2 - Structure, localization, and promoter characterization
AU - Korver, Wouter
AU - Roose, Jeroen
AU - Heinen, Klaartje
AU - Weghuis, Daniël Olde
AU - Bruijn, Diederik De
AU - Van Kessel, Ad Geurts
AU - Clevers, Hans
PY - 1997/12/15
Y1 - 1997/12/15
N2 - We recently identified the winged-helix/fork head transcription factor Trident in mouse and described its expression in cycling cells. Here we report the isolation and characterization of the human TRIDENT (HGMW-approved symbol FKHL16) cDNA and gene. Homology between the human and the mouse Trident proteins was 79%. The gene consists of 10 exons and is located on chromosome 12 band p13. The winged-helix DNA-binding domain is encoded on three exons. Analysis of the promoter in synchronized Rat-1 fibroblasts revealed a fragment of 300 bases responsible for the cell cycle-specific expression of the TRIDENT gene.
AB - We recently identified the winged-helix/fork head transcription factor Trident in mouse and described its expression in cycling cells. Here we report the isolation and characterization of the human TRIDENT (HGMW-approved symbol FKHL16) cDNA and gene. Homology between the human and the mouse Trident proteins was 79%. The gene consists of 10 exons and is located on chromosome 12 band p13. The winged-helix DNA-binding domain is encoded on three exons. Analysis of the promoter in synchronized Rat-1 fibroblasts revealed a fragment of 300 bases responsible for the cell cycle-specific expression of the TRIDENT gene.
UR - http://www.scopus.com/inward/record.url?scp=0031573921&partnerID=8YFLogxK
U2 - 10.1006/geno.1997.5065
DO - 10.1006/geno.1997.5065
M3 - Article
C2 - 9441747
AN - SCOPUS:0031573921
SN - 0888-7543
VL - 46
SP - 435
EP - 442
JO - Genomics
JF - Genomics
IS - 3
ER -