The human TRIDENT/HFH- 11/FKHL16 gene: Structure, localization, and promoter characterization

Wouter Korver; Jeroen Roose; Klaartje Heinen; Daniël Olde Weghuis; Diederik De Bruijn; Ad Geurts Van Kessel; Hans Clevers

doi:10.1006/geno.1997.5065

The human TRIDENT/HFH- 11/FKHL16 gene: Structure, localization, and promoter characterization

Wouter Korver
, Jeroen Roose
, Klaartje Heinen
, Daniël Olde Weghuis
, Diederik De Bruijn
, Ad Geurts Van Kessel
, Hans Clevers

Research output: Contribution to journal › Article › peer-review

108 Citations (Scopus)

Abstract

We recently identified the winged-helix/fork head transcription factor Trident in mouse and described its expression in cycling cells. Here we report the isolation and characterization of the human TRIDENT (HGMW-approved symbol FKHL16) cDNA and gene. Homology between the human and the mouse Trident proteins was 79%. The gene consists of 10 exons and is located on chromosome 12 band p13. The winged-helix DNA-binding domain is encoded on three exons. Analysis of the promoter in synchronized Rat-1 fibroblasts revealed a fragment of 300 bases responsible for the cell cycle-specific expression of the TRIDENT gene.

Original language	English
Pages (from-to)	435-442
Number of pages	8
Journal	Genomics
Volume	46
Issue number	3
DOIs	https://doi.org/10.1006/geno.1997.5065
Publication status	Published - 15 Dec 1997
Externally published	Yes

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title = "The human TRIDENT/HFH- 11/FKHL16 gene: Structure, localization, and promoter characterization",

abstract = "We recently identified the winged-helix/fork head transcription factor Trident in mouse and described its expression in cycling cells. Here we report the isolation and characterization of the human TRIDENT (HGMW-approved symbol FKHL16) cDNA and gene. Homology between the human and the mouse Trident proteins was 79\%. The gene consists of 10 exons and is located on chromosome 12 band p13. The winged-helix DNA-binding domain is encoded on three exons. Analysis of the promoter in synchronized Rat-1 fibroblasts revealed a fragment of 300 bases responsible for the cell cycle-specific expression of the TRIDENT gene.",

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AU - Korver, Wouter

AU - Roose, Jeroen

AU - Heinen, Klaartje

AU - Weghuis, Daniël Olde

AU - Bruijn, Diederik De

AU - Van Kessel, Ad Geurts

AU - Clevers, Hans

PY - 1997/12/15

Y1 - 1997/12/15

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AB - We recently identified the winged-helix/fork head transcription factor Trident in mouse and described its expression in cycling cells. Here we report the isolation and characterization of the human TRIDENT (HGMW-approved symbol FKHL16) cDNA and gene. Homology between the human and the mouse Trident proteins was 79%. The gene consists of 10 exons and is located on chromosome 12 band p13. The winged-helix DNA-binding domain is encoded on three exons. Analysis of the promoter in synchronized Rat-1 fibroblasts revealed a fragment of 300 bases responsible for the cell cycle-specific expression of the TRIDENT gene.

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JO - Genomics

JF - Genomics

IS - 3

ER -

The human TRIDENT/HFH- 11/FKHL16 gene: Structure, localization, and promoter characterization

Abstract

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