The interplay of epigenetic marks during stem cell differentiation and development

Research output: Contribution to journalReview articlepeer-review

318 Citations (Scopus)


Chromatin, the template for epigenetic regulation, is a highly dynamic entity that is constantly reshaped during early development and differentiation. Epigenetic modification of chromatin provides the necessary plasticity for cells to respond to environmental and positional cues, and enables the maintenance of acquired information without changing the DNA sequence. The mechanisms involve, among others, chemical modifications of chromatin, changes in chromatin constituents and reconfiguration of chromatin interactions and 3D structure. New advances in genome-wide technologies have paved the way towards an integrative view of epigenome dynamics during cell state transitions, and recent findings in embryonic stem cells highlight how the interplay between different epigenetic layers reshapes the transcriptional landscape.

Original languageEnglish
Pages (from-to)643-658
Number of pages16
JournalNature Reviews Genetics
Issue number11
Publication statusPublished - 1 Nov 2017
Externally publishedYes


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