The molecular signature of oncofusion proteins in acute myeloid leukemia

Joost H.A. Martens, Henk G. Stunnenberg

Research output: Contribution to journalReview articlepeer-review

80 Citations (Scopus)

Abstract

Acute myeloid leukemia (AML) associated translocations often cause gene fusions that encode oncofusion proteins. Although many of the breakpoints involved in chromosomal translocations have been cloned, in most cases the role of the chimeric proteins in tumorigenesis is not elucidated. Here we will discuss the fusion proteins of the 4 most common translocations associated with AML as well as the common molecular mechanisms that these four and other fusion proteins utilize to transform progenitor cells. Intriguingly, although the individual partners within the fusion proteins represent a wide variety of cellular functions, at the molecular level many commodities can be found.

Original languageEnglish
Pages (from-to)2662-2669
Number of pages8
JournalFEBS Letters
Volume584
Issue number12
DOIs
Publication statusPublished - Jun 2010
Externally publishedYes

Keywords

  • Acute myeloid leukemia
  • Epigenetic
  • Oncofusion protein
  • Transcriptional regulation

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