TY - JOUR
T1 - The multidrug resistance protein family
AU - Borst, Piet
AU - Evers, Raymond
AU - Kool, Marcel
AU - Wijnholds, Jan
N1 - Funding Information:
Our experimental work on MRPs is supported by grants from the Dutch Cancer Society to P.B.
PY - 1999/12/6
Y1 - 1999/12/6
N2 - The human multidrug resistance protein (MRP) family contains at least six members: MRP1, the godfather of the family and well known as the multidrug resistance protein, and five homologs, called MRP2-6. In this review, we summarize what is known about the protein structure, the expression in tissues, the routing in cells, the physiological functions, the substrate specificity, and the role in multidrug resistance of the individual members of the MRP family.
AB - The human multidrug resistance protein (MRP) family contains at least six members: MRP1, the godfather of the family and well known as the multidrug resistance protein, and five homologs, called MRP2-6. In this review, we summarize what is known about the protein structure, the expression in tissues, the routing in cells, the physiological functions, the substrate specificity, and the role in multidrug resistance of the individual members of the MRP family.
KW - Cisplatin
KW - Glutathione-drug conjugate pump
KW - GSH
KW - Multidrug resistance
KW - Multidrug resistance protein
KW - Protein routing
UR - http://www.scopus.com/inward/record.url?scp=0032750225&partnerID=8YFLogxK
U2 - 10.1016/S0005-2736(99)00167-4
DO - 10.1016/S0005-2736(99)00167-4
M3 - Review article
C2 - 10581366
AN - SCOPUS:0032750225
SN - 0005-2736
VL - 1461
SP - 347
EP - 357
JO - Biochimica et Biophysica Acta - Biomembranes
JF - Biochimica et Biophysica Acta - Biomembranes
IS - 2
ER -