The multidrug resistance protein family

Piet Borst, Raymond Evers, Marcel Kool, Jan Wijnholds

Research output: Contribution to journalReview articlepeer-review

596 Citations (Scopus)

Abstract

The human multidrug resistance protein (MRP) family contains at least six members: MRP1, the godfather of the family and well known as the multidrug resistance protein, and five homologs, called MRP2-6. In this review, we summarize what is known about the protein structure, the expression in tissues, the routing in cells, the physiological functions, the substrate specificity, and the role in multidrug resistance of the individual members of the MRP family.

Original languageEnglish
Pages (from-to)347-357
Number of pages11
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1461
Issue number2
DOIs
Publication statusPublished - 6 Dec 1999
Externally publishedYes

Keywords

  • Cisplatin
  • Glutathione-drug conjugate pump
  • GSH
  • Multidrug resistance
  • Multidrug resistance protein
  • Protein routing

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