The multidrug resistance protein family

Piet Borst; Raymond Evers; Marcel Kool; Jan Wijnholds

doi:10.1016/S0005-2736(99)00167-4

The multidrug resistance protein family

Piet Borst
, Raymond Evers
, Marcel Kool
, Jan Wijnholds

Research output: Contribution to journal › Review article › peer-review

609 Citations (Scopus)

Abstract

The human multidrug resistance protein (MRP) family contains at least six members: MRP1, the godfather of the family and well known as the multidrug resistance protein, and five homologs, called MRP2-6. In this review, we summarize what is known about the protein structure, the expression in tissues, the routing in cells, the physiological functions, the substrate specificity, and the role in multidrug resistance of the individual members of the MRP family.

Original language	English
Pages (from-to)	347-357
Number of pages	11
Journal	Biochimica et Biophysica Acta - Biomembranes
Volume	1461
Issue number	2
DOIs	https://doi.org/10.1016/S0005-2736(99)00167-4
Publication status	Published - 6 Dec 1999
Externally published	Yes

Keywords

Cisplatin
GSH
Glutathione-drug conjugate pump
Multidrug resistance
Multidrug resistance protein
Protein routing

Access to Document

10.1016/S0005-2736(99)00167-4

Cite this

@article{a2f52a29ea8c4a86931be28fe95c18d7,

title = "The multidrug resistance protein family",

abstract = "The human multidrug resistance protein (MRP) family contains at least six members: MRP1, the godfather of the family and well known as the multidrug resistance protein, and five homologs, called MRP2-6. In this review, we summarize what is known about the protein structure, the expression in tissues, the routing in cells, the physiological functions, the substrate specificity, and the role in multidrug resistance of the individual members of the MRP family.",

keywords = "Cisplatin, GSH, Glutathione-drug conjugate pump, Multidrug resistance, Multidrug resistance protein, Protein routing",

author = "Piet Borst and Raymond Evers and Marcel Kool and Jan Wijnholds",

note = "Funding Information: Our experimental work on MRPs is supported by grants from the Dutch Cancer Society to P.B. ",

year = "1999",

month = dec,

day = "6",

doi = "10.1016/S0005-2736(99)00167-4",

language = "English",

volume = "1461",

pages = "347--357",

journal = "Biochimica et Biophysica Acta - Biomembranes",

issn = "0005-2736",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - The multidrug resistance protein family

AU - Borst, Piet

AU - Evers, Raymond

AU - Kool, Marcel

AU - Wijnholds, Jan

N1 - Funding Information: Our experimental work on MRPs is supported by grants from the Dutch Cancer Society to P.B.

PY - 1999/12/6

Y1 - 1999/12/6

N2 - The human multidrug resistance protein (MRP) family contains at least six members: MRP1, the godfather of the family and well known as the multidrug resistance protein, and five homologs, called MRP2-6. In this review, we summarize what is known about the protein structure, the expression in tissues, the routing in cells, the physiological functions, the substrate specificity, and the role in multidrug resistance of the individual members of the MRP family.

AB - The human multidrug resistance protein (MRP) family contains at least six members: MRP1, the godfather of the family and well known as the multidrug resistance protein, and five homologs, called MRP2-6. In this review, we summarize what is known about the protein structure, the expression in tissues, the routing in cells, the physiological functions, the substrate specificity, and the role in multidrug resistance of the individual members of the MRP family.

KW - Cisplatin

KW - GSH

KW - Glutathione-drug conjugate pump

KW - Multidrug resistance

KW - Multidrug resistance protein

KW - Protein routing

UR - https://www.scopus.com/pages/publications/0032750225

U2 - 10.1016/S0005-2736(99)00167-4

DO - 10.1016/S0005-2736(99)00167-4

M3 - Review article

C2 - 10581366

AN - SCOPUS:0032750225

SN - 0005-2736

VL - 1461

SP - 347

EP - 357

JO - Biochimica et Biophysica Acta - Biomembranes

JF - Biochimica et Biophysica Acta - Biomembranes

IS - 2

ER -

The multidrug resistance protein family

Abstract

Keywords

Access to Document

Fingerprint

Cite this