The Prognostic Value of Eight Immunohistochemical Markers Expressed in the Tumor Microenvironment and on Hodgkin Reed-Sternberg Cells in Pediatric Patients With Classical Hodgkin Lymphoma

Eline A.M. Zijtregtop, Ilse Tromp, Rana Dandis, Christian M. Zwaan, King H. Lam, Friederike A.G. Meyer-Wentrup, Auke Beishuizen

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1 Citation (Scopus)

Abstract

Immunohistochemical markers are associated with treatment outcome in adults with classical Hodgkin Lymphoma (cHL). Studies in children are scarce and inconsistent. We investigated in 67 children with cHL, whether the expression of CD15, CD30, PAX5, PD-1, PD-L1, CD68, CD163 and TARC at diagnosis is associated with disease free survival (DFS) and with interim remission status. Low CD15 and low TARC expression were associated with relapsed disease. Low expression of PD-L1 was associated with complete remission at interim PET-scan. Our data suggest a difference between pediatric and adult cHL. This underlines the importance of future research into specific prognostic factors in pediatric cHL, indispensable for improvement of treatment in this population.

Original languageEnglish
Article number1610482
Pages (from-to)1610482
JournalPathology and Oncology Research
Volume28
DOIs
Publication statusPublished - 11 Aug 2022

Keywords

  • children
  • classical Hodgkin lymphoma
  • immunohistochemical markers
  • pediatric
  • prognosis
  • prognostic markers
  • prognostic value
  • Prognosis
  • B7-H1 Antigen
  • Hodgkin Disease
  • Humans
  • Tumor Microenvironment
  • Biomarkers
  • Adult
  • Child
  • Reed-Sternberg Cells

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