The region of common allelic losses in sporadic renal cell carcinoma is bordered by the loci D3S2 and THRB

Annemarie H. van der Hout; Pieter van der Vlies; Cisca Wijmenga; Frederic P. Li; J. Wolter Oosterhuis; Charles H.C.M. Buys

doi:10.1016/0888-7543(91)90060-R

The region of common allelic losses in sporadic renal cell carcinoma is bordered by the loci D3S2 and THRB

Annemarie H. van der Hout
, Pieter van der Vlies
, Cisca Wijmenga
, Frederic P. Li
, J. Wolter Oosterhuis
, Charles H.C.M. Buys

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Cytogenetic studies and DNA analysis have shown that the short arm of chromosome 3 is the region in the genome that is commonly deleted in renal cell carcinoma. By studying loss of heterozygosity in 41 matched tumor/normal kidney tissue pairs, we could delimit the commonly deleted part of 3p to the region between the loci THRB (in 3p24) and D3S2 (in 3p21). The regions on 3p suggested to be involved in the Von Hippel-Lindau syndrome and in hereditary renal cell carcinoma are both outside this smallest region of overlapping deletions. Consequently, renal cell cancer would be an illustration of the possibility that different genes cause the same type of tumor.

Original language	English
Pages (from-to)	537-542
Number of pages	6
Journal	Genomics
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/0888-7543(91)90060-R
Publication status	Published - Nov 1991
Externally published	Yes

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@article{d95b61c9dbd9401f83332cac1d421b29,

title = "The region of common allelic losses in sporadic renal cell carcinoma is bordered by the loci D3S2 and THRB",

abstract = "Cytogenetic studies and DNA analysis have shown that the short arm of chromosome 3 is the region in the genome that is commonly deleted in renal cell carcinoma. By studying loss of heterozygosity in 41 matched tumor/normal kidney tissue pairs, we could delimit the commonly deleted part of 3p to the region between the loci THRB (in 3p24) and D3S2 (in 3p21). The regions on 3p suggested to be involved in the Von Hippel-Lindau syndrome and in hereditary renal cell carcinoma are both outside this smallest region of overlapping deletions. Consequently, renal cell cancer would be an illustration of the possibility that different genes cause the same type of tumor.",

author = "\{van der Hout\}, \{Annemarie H.\} and \{van der Vlies\}, Pieter and Cisca Wijmenga and Li, \{Frederic P.\} and Oosterhuis, \{J. Wolter\} and Buys, \{Charles H.C.M.\}",

note = "Funding Information: This work was supported by a grant from Cancer Foundation. We thank Drs. W. Bradley, jean, A. Driesel, S. Naylor, P. Rabbit@ U. Rapp, making chromosome 3 probes available for this the Netherlands B. Carritt, A. De-and R. White for study.",

year = "1991",

month = nov,

doi = "10.1016/0888-7543(91)90060-R",

language = "English",

volume = "11",

pages = "537--542",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press Inc.",

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TY - JOUR

T1 - The region of common allelic losses in sporadic renal cell carcinoma is bordered by the loci D3S2 and THRB

AU - van der Hout, Annemarie H.

AU - van der Vlies, Pieter

AU - Wijmenga, Cisca

AU - Li, Frederic P.

AU - Oosterhuis, J. Wolter

AU - Buys, Charles H.C.M.

N1 - Funding Information: This work was supported by a grant from Cancer Foundation. We thank Drs. W. Bradley, jean, A. Driesel, S. Naylor, P. Rabbit@ U. Rapp, making chromosome 3 probes available for this the Netherlands B. Carritt, A. De-and R. White for study.

PY - 1991/11

Y1 - 1991/11

N2 - Cytogenetic studies and DNA analysis have shown that the short arm of chromosome 3 is the region in the genome that is commonly deleted in renal cell carcinoma. By studying loss of heterozygosity in 41 matched tumor/normal kidney tissue pairs, we could delimit the commonly deleted part of 3p to the region between the loci THRB (in 3p24) and D3S2 (in 3p21). The regions on 3p suggested to be involved in the Von Hippel-Lindau syndrome and in hereditary renal cell carcinoma are both outside this smallest region of overlapping deletions. Consequently, renal cell cancer would be an illustration of the possibility that different genes cause the same type of tumor.

AB - Cytogenetic studies and DNA analysis have shown that the short arm of chromosome 3 is the region in the genome that is commonly deleted in renal cell carcinoma. By studying loss of heterozygosity in 41 matched tumor/normal kidney tissue pairs, we could delimit the commonly deleted part of 3p to the region between the loci THRB (in 3p24) and D3S2 (in 3p21). The regions on 3p suggested to be involved in the Von Hippel-Lindau syndrome and in hereditary renal cell carcinoma are both outside this smallest region of overlapping deletions. Consequently, renal cell cancer would be an illustration of the possibility that different genes cause the same type of tumor.

UR - https://www.scopus.com/pages/publications/0026075496

U2 - 10.1016/0888-7543(91)90060-R

DO - 10.1016/0888-7543(91)90060-R

M3 - Article

C2 - 1685475

AN - SCOPUS:0026075496

SN - 0888-7543

VL - 11

SP - 537

EP - 542

JO - Genomics

JF - Genomics

IS - 3

ER -

The region of common allelic losses in sporadic renal cell carcinoma is bordered by the loci D3S2 and THRB

Abstract

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