The road to clinical use of high-intensity focused ultrasound for liver cancer: Technical and clinical consensus

Jean Francois Aubry, Kim Butts Pauly, Chrit Moonen, Gailter Haar, Mario Ries, Rares Salomir, Sham Sokka, Kevin Michael Sekins, Yerucham Shapira, Fangwei Ye, Heather Huff-Simonin, Matt Eames, Arik Hananel, Neal Kassell, Alessandro Napoli, Joo Ha Hwang, Feng Wu, Lian Zhang, Andreas Melzer, Young sun KimWladyslaw M. Gedroyc

Research output: Contribution to journalReview articlepeer-review

81 Citations (Scopus)

Abstract

Clinical use of high-intensity focused ultrasound (HIFU) under ultrasound or MR guidance as a non-invasive method for treating tumors is rapidly increasing. Tens of thousands of patients have been treated for uterine fibroid, benign prostate hyperplasia, bone metastases, or prostate cancer. Despite the methods' clinical potential, the liver is a particularly challenging organ for HIFU treatment due to the combined effect of respiratory-induced liver motion, partial blocking by the rib cage, and high perfusion/flow. Several technical and clinical solutions have been developed by various groups during the past 15 years to compensate for these problems. A review of current unmet clinical needs is given here, as well as a consensus from a panel of experts about technical and clinical requirements for upcoming pilot and pivotal studies in order to accelerate the development and adoption of focused ultrasound for the treatment of primary and secondary liver cancer.

Original languageEnglish
Article number13
JournalJournal of Therapeutic Ultrasound
Volume1
Issue number1
DOIs
Publication statusPublished - 1 Aug 2013
Externally publishedYes

Keywords

  • Focused ultrasound
  • High-intensity ultrasound
  • Liver cancer
  • Non-invasive surgery
  • Ultrasound

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