The role of constitutive activation of FMS-related tyrosine kinase-3 and NRas/KRas mutational status in infants with KMT2A-rearranged acute lymphoblastic leukemia

Henning Fedders; Ameera Alsadeq; Juliane Schmäh; Fotini Vogiatzi; Martin Zimmermann; Anja Möricke; Lennart Lenk; Udo zur Stadt; Martin A. Horstmann; Rob Pieters; Martin Schrappe; Martin Stanulla; Gunnar Cario; Denis M. Schewe

doi:10.3324/haematol.2017.169870

The role of constitutive activation of FMS-related tyrosine kinase-3 and NRas/KRas mutational status in infants with KMT2A-rearranged acute lymphoblastic leukemia

Henning Fedders, Ameera Alsadeq, Juliane Schmäh, Fotini Vogiatzi, Martin Zimmermann, Anja Möricke, Lennart Lenk, Udo zur Stadt, Martin A. Horstmann, Rob Pieters, Martin Schrappe, Martin Stanulla, Gunnar Cario, Denis M. Schewe

Group Pieters

Research output: Contribution to journal › Letter › peer-review

16 Citations (Scopus)

Original language	English
Pages (from-to)	e438-e442
Journal	Haematologica
Volume	102
Issue number	11
DOIs	https://doi.org/10.3324/haematol.2017.169870
Publication status	Published - 27 Oct 2017

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Fedders, H., Alsadeq, A., Schmäh, J., Vogiatzi, F., Zimmermann, M., Möricke, A., Lenk, L., zur Stadt, U., Horstmann, M. A., Pieters, R., Schrappe, M., Stanulla, M., Cario, G., & Schewe, D. M. (2017). The role of constitutive activation of FMS-related tyrosine kinase-3 and NRas/KRas mutational status in infants with KMT2A-rearranged acute lymphoblastic leukemia. Haematologica, 102(11), e438-e442. https://doi.org/10.3324/haematol.2017.169870

@article{c1ef0ac124bd423cb74c42a7d5eda082,

title = "The role of constitutive activation of FMS-related tyrosine kinase-3 and NRas/KRas mutational status in infants with KMT2A-rearranged acute lymphoblastic leukemia",

author = "Henning Fedders and Ameera Alsadeq and Juliane Schm{\"a}h and Fotini Vogiatzi and Martin Zimmermann and Anja M{\"o}ricke and Lennart Lenk and {zur Stadt}, Udo and Horstmann, {Martin A.} and Rob Pieters and Martin Schrappe and Martin Stanulla and Gunnar Cario and Schewe, {Denis M.}",

note = "Funding Information: Funding: this work was supported by the European Union{\textquoteright}s Seventh Framework Program (FP7/2007-2013) under the project European Network for Cancer Research in Children and Adolescents (ENCCA), grant agreement HEALTH-F2-2011-261474. J. S. is supported by the Madeleine Schickedanz-Kinderkrebs-Stiftung. D. M. S. is supported by a Max-Eder Junior Research Grant by the Deutsche Krebshilfe e. V. and by the Wilhelm-Sander Stiftung. Funding Information: 1Department of Pediatrics, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany; 2Pediatric Hematology and Oncology, Hannover Medical School, Germany; 3Research Institute Children{\textquoteright}s Cancer Center and Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Germany; and 4Princess M{\'a}xima Center for Pediatric Oncology, Utrecht, the Netherlands Acknowledgments: we thank Birthe Fedders, Katrin Timm-Richert and Katrin Neumann for excellent technical assistance. We thank the Institute of Clinical Molecular Biology in Kiel for providing Sanger sequencing as supported in part by the DFG Cluster of Excellence “Inflammation at Interfaces” and {"}Future Ocean{"}. We thank Sandra Greve, Tanja Henke and Stefanie Arndt for technical support.",

year = "2017",

month = oct,

day = "27",

doi = "10.3324/haematol.2017.169870",

language = "English",

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Fedders, H, Alsadeq, A, Schmäh, J, Vogiatzi, F, Zimmermann, M, Möricke, A, Lenk, L, zur Stadt, U, Horstmann, MA, Pieters, R, Schrappe, M, Stanulla, M, Cario, G & Schewe, DM 2017, 'The role of constitutive activation of FMS-related tyrosine kinase-3 and NRas/KRas mutational status in infants with KMT2A-rearranged acute lymphoblastic leukemia', Haematologica, vol. 102, no. 11, pp. e438-e442. https://doi.org/10.3324/haematol.2017.169870

TY - JOUR

T1 - The role of constitutive activation of FMS-related tyrosine kinase-3 and NRas/KRas mutational status in infants with KMT2A-rearranged acute lymphoblastic leukemia

AU - Fedders, Henning

AU - Alsadeq, Ameera

AU - Schmäh, Juliane

AU - Vogiatzi, Fotini

AU - Zimmermann, Martin

AU - Möricke, Anja

AU - Lenk, Lennart

AU - zur Stadt, Udo

AU - Horstmann, Martin A.

AU - Pieters, Rob

AU - Schrappe, Martin

AU - Stanulla, Martin

AU - Cario, Gunnar

AU - Schewe, Denis M.

N1 - Funding Information: Funding: this work was supported by the European Union’s Seventh Framework Program (FP7/2007-2013) under the project European Network for Cancer Research in Children and Adolescents (ENCCA), grant agreement HEALTH-F2-2011-261474. J. S. is supported by the Madeleine Schickedanz-Kinderkrebs-Stiftung. D. M. S. is supported by a Max-Eder Junior Research Grant by the Deutsche Krebshilfe e. V. and by the Wilhelm-Sander Stiftung. Funding Information: 1Department of Pediatrics, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany; 2Pediatric Hematology and Oncology, Hannover Medical School, Germany; 3Research Institute Children’s Cancer Center and Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Germany; and 4Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands Acknowledgments: we thank Birthe Fedders, Katrin Timm-Richert and Katrin Neumann for excellent technical assistance. We thank the Institute of Clinical Molecular Biology in Kiel for providing Sanger sequencing as supported in part by the DFG Cluster of Excellence “Inflammation at Interfaces” and "Future Ocean". We thank Sandra Greve, Tanja Henke and Stefanie Arndt for technical support.

PY - 2017/10/27

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DO - 10.3324/haematol.2017.169870

M3 - Letter

C2 - 28838992

AN - SCOPUS:85032656168

SN - 0390-6078

VL - 102

SP - e438-e442

JO - Haematologica

JF - Haematologica

IS - 11

ER -