The role of isolated limb perfusion for melanoma confined to the extremities

Alexander M.M. Eggermont; Albertus N. Van Geel; Johannes H.W. De Wilt; Timo L.M. Ten Hagen

doi:10.1016/S0039-6109(02)00095-6

The role of isolated limb perfusion for melanoma confined to the extremities

Alexander M.M. Eggermont
, Albertus N. Van Geel
, Johannes H.W. De Wilt
, Timo L.M. Ten Hagen

Research output: Contribution to journal › Review article › peer-review

21 Citations (Scopus)

Abstract

Isolated limb perfusion with Melphalan is the best treatment option to control symptomatic multiple small in-transit metastases. When lesions are bulky, Isolated Limb Perfusion (ILP) with Tumor Necrosis Factor (TNF) + Melphalan is superior as in soft tissue sarcoma. TNF changes the pathophysiology, greatly enhances the uptake of Melphalan and destructs selectively the vasculature of large tumors. To date, ILP is not indicated in an adjuvant setting.

Original language	English
Pages (from-to)	371-384
Number of pages	14
Journal	Surgical Clinics of North America
Volume	83
Issue number	2
DOIs	https://doi.org/10.1016/S0039-6109(02)00095-6
Publication status	Published - 1 Apr 2003
Externally published	Yes

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Cite this

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title = "The role of isolated limb perfusion for melanoma confined to the extremities",

abstract = "Isolated limb perfusion with Melphalan is the best treatment option to control symptomatic multiple small in-transit metastases. When lesions are bulky, Isolated Limb Perfusion (ILP) with Tumor Necrosis Factor (TNF) + Melphalan is superior as in soft tissue sarcoma. TNF changes the pathophysiology, greatly enhances the uptake of Melphalan and destructs selectively the vasculature of large tumors. To date, ILP is not indicated in an adjuvant setting.",

author = "Eggermont, \{Alexander M.M.\} and \{Van Geel\}, \{Albertus N.\} and \{De Wilt\}, \{Johannes H.W.\} and \{Ten Hagen\}, \{Timo L.M.\}",

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T1 - The role of isolated limb perfusion for melanoma confined to the extremities

AU - Eggermont, Alexander M.M.

AU - Van Geel, Albertus N.

AU - De Wilt, Johannes H.W.

AU - Ten Hagen, Timo L.M.

PY - 2003/4/1

Y1 - 2003/4/1

N2 - Isolated limb perfusion with Melphalan is the best treatment option to control symptomatic multiple small in-transit metastases. When lesions are bulky, Isolated Limb Perfusion (ILP) with Tumor Necrosis Factor (TNF) + Melphalan is superior as in soft tissue sarcoma. TNF changes the pathophysiology, greatly enhances the uptake of Melphalan and destructs selectively the vasculature of large tumors. To date, ILP is not indicated in an adjuvant setting.

AB - Isolated limb perfusion with Melphalan is the best treatment option to control symptomatic multiple small in-transit metastases. When lesions are bulky, Isolated Limb Perfusion (ILP) with Tumor Necrosis Factor (TNF) + Melphalan is superior as in soft tissue sarcoma. TNF changes the pathophysiology, greatly enhances the uptake of Melphalan and destructs selectively the vasculature of large tumors. To date, ILP is not indicated in an adjuvant setting.

UR - https://www.scopus.com/pages/publications/0037398375

U2 - 10.1016/S0039-6109(02)00095-6

DO - 10.1016/S0039-6109(02)00095-6

M3 - Review article

C2 - 12744614

AN - SCOPUS:0037398375

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VL - 83

SP - 371

EP - 384

JO - Surgical Clinics of North America

JF - Surgical Clinics of North America

IS - 2

ER -

The role of isolated limb perfusion for melanoma confined to the extremities

Abstract

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