The tumor microenvironment and immune targeting therapy in pediatric renal tumors

Amy B. Hont; Benoit Dumont; Kathryn S. Sutton; John Anderson; Alex Kentsis; Jarno Drost; Andrew L. Hong; Arnauld Verschuur

doi:10.1002/pbc.30110

The tumor microenvironment and immune targeting therapy in pediatric renal tumors

Amy B. Hont
, Benoit Dumont
, Kathryn S. Sutton
, John Anderson
, Alex Kentsis
, Jarno Drost
, Andrew L. Hong
, Arnauld Verschuur

Group Drost

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

This review highlights the role of several immunomodulating elements contributing to the tumor microenvironment of various pediatric renal tumors including Wilms tumor. The roles of innate and adaptive immune cells in renal tumors are summarized as well as immunomodulatory cytokines and other proteins. The expression and the predictive role of checkpoint modulators like PD-L1 and immunomodulating proteins like glypican-3, B7-H3, COX-2 are highlighted with a translational view toward potential therapeutic innovations. We further discuss the current state of preclinical models in advancing this field of study. Finally, examples of clinical trials of immunomodulating strategies such as monoclonal antibodies and chimeric antigen receptor T (CAR-T) cells for relapsed/refractory/progressive pediatric renal tumors are described.

Original language	English
Article number	e30110
Pages (from-to)	e30110
Journal	Pediatric Blood and Cancer
Volume	70 Suppl 2
Issue number	S2
DOIs	https://doi.org/10.1002/pbc.30110
Publication status	Published - May 2023

Keywords

Child
Humans
Tumor Microenvironment
B7-H1 Antigen
Kidney Neoplasms/drug therapy
Immunomodulation
Antibodies, Monoclonal/therapeutic use

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10.1002/pbc.30110

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title = "The tumor microenvironment and immune targeting therapy in pediatric renal tumors",

abstract = "This review highlights the role of several immunomodulating elements contributing to the tumor microenvironment of various pediatric renal tumors including Wilms tumor. The roles of innate and adaptive immune cells in renal tumors are summarized as well as immunomodulatory cytokines and other proteins. The expression and the predictive role of checkpoint modulators like PD-L1 and immunomodulating proteins like glypican-3, B7-H3, COX-2 are highlighted with a translational view toward potential therapeutic innovations. We further discuss the current state of preclinical models in advancing this field of study. Finally, examples of clinical trials of immunomodulating strategies such as monoclonal antibodies and chimeric antigen receptor T (CAR-T) cells for relapsed/refractory/progressive pediatric renal tumors are described.",

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AU - Hont, Amy B.

AU - Dumont, Benoit

AU - Sutton, Kathryn S.

AU - Anderson, John

AU - Kentsis, Alex

AU - Drost, Jarno

AU - Hong, Andrew L.

AU - Verschuur, Arnauld

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The tumor microenvironment and immune targeting therapy in pediatric renal tumors

Abstract

Keywords

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