The Virtual Child

Richard J Gilbertson; Sam Behjati; Anna-Lisa Böttcher; Marianne E Bronner; Matthew Burridge; Henrick Clausing; Harry Clifford; Tracey Danaher; Laura K Donovan; Jarno Drost; Alexander M M Eggermont; Chris Emerson; Mona G Flores; Petra Hamerlik; Nada Jabado; Andrew Jones; Henrick Kaessmann; Claudia L Kleinman; Marcel Kool; Lena M Kutscher; Gavin Lindberg; Emily Linnane; John C Marioni; John M Maris; Michelle Monje; Alexandra Macaskill; Steven Niederer; Paul A Northcott; Elizabeth Peeters; Willemijn Plieger-van Solkema; Liane Preußner; Anne C Rios; Karsten Rippe; Peter Sandford; Nikolaos G Sgourakis; Adam Shlien; Pete Smith; Karin Straathof; Patrick J Sullivan; Mario L Suvà; Michael D Taylor; Emma Thompson; Roser Vento-Tormo; Brandon J Wainwright; Robert J Wechsler-Reya; Frank Westermann; Shannon Winslade; Bissan Al-Lazikani; Stefan M Pfister

doi:10.1158/2159-8290.CD-23-1500

The Virtual Child

Richard J Gilbertson, Sam Behjati, Anna-Lisa Böttcher, Marianne E Bronner, Matthew Burridge, Henrick Clausing, Harry Clifford, Tracey Danaher, Laura K Donovan, Jarno Drost, Alexander M M Eggermont, Chris Emerson, Mona G Flores, Petra Hamerlik, Nada Jabado, Andrew Jones, Henrick Kaessmann, Claudia L Kleinman, Marcel Kool, Lena M KutscherGavin Lindberg, Emily Linnane, John C Marioni, John M Maris, Michelle Monje, Alexandra Macaskill, Steven Niederer, Paul A Northcott, Elizabeth Peeters, Willemijn Plieger-van Solkema, Liane Preußner, Anne C Rios, Karsten Rippe, Peter Sandford, Nikolaos G Sgourakis, Adam Shlien, Pete Smith, Karin Straathof, Patrick J Sullivan, Mario L Suvà, Michael D Taylor, Emma Thompson, Roser Vento-Tormo, Brandon J Wainwright, Robert J Wechsler-Reya, Frank Westermann, Shannon Winslade, Bissan Al-Lazikani, Stefan M Pfister

Research output: Contribution to journal › Article › peer-review

Abstract

We are building the world's first Virtual Child-a computer model of normal and cancerous human development at the level of each individual cell. The Virtual Child will "develop cancer" that we will subject to unlimited virtual clinical trials that pinpoint, predict, and prioritize potential new treatments, bringing forward the day when no child dies of cancer, giving each one the opportunity to lead a full and healthy life.

Original language	English
Pages (from-to)	663-668
Number of pages	6
Journal	Cancer discovery
Volume	14
Issue number	4
DOIs	https://doi.org/10.1158/2159-8290.CD-23-1500
Publication status	Published - Jan 2024

Keywords

Humans
Neoplasms/genetics

Access to Document

10.1158/2159-8290.CD-23-1500

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Gilbertson, R. J., Behjati, S., Böttcher, A.-L., Bronner, M. E., Burridge, M., Clausing, H., Clifford, H., Danaher, T., Donovan, L. K., Drost, J., Eggermont, A. M. M., Emerson, C., Flores, M. G., Hamerlik, P., Jabado, N., Jones, A., Kaessmann, H., Kleinman, C. L., Kool, M., ... Pfister, S. M. (2024). The Virtual Child. Cancer discovery, 14(4), 663-668. https://doi.org/10.1158/2159-8290.CD-23-1500

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title = "The Virtual Child",

abstract = "We are building the world's first Virtual Child-a computer model of normal and cancerous human development at the level of each individual cell. The Virtual Child will {"}develop cancer{"} that we will subject to unlimited virtual clinical trials that pinpoint, predict, and prioritize potential new treatments, bringing forward the day when no child dies of cancer, giving each one the opportunity to lead a full and healthy life.",

keywords = "Humans, Neoplasms/genetics",

author = "Gilbertson, {Richard J} and Sam Behjati and Anna-Lisa B{\"o}ttcher and Bronner, {Marianne E} and Matthew Burridge and Henrick Clausing and Harry Clifford and Tracey Danaher and Donovan, {Laura K} and Jarno Drost and Eggermont, {Alexander M M} and Chris Emerson and Flores, {Mona G} and Petra Hamerlik and Nada Jabado and Andrew Jones and Henrick Kaessmann and Kleinman, {Claudia L} and Marcel Kool and Kutscher, {Lena M} and Gavin Lindberg and Emily Linnane and Marioni, {John C} and Maris, {John M} and Michelle Monje and Alexandra Macaskill and Steven Niederer and Northcott, {Paul A} and Elizabeth Peeters and {Plieger-van Solkema}, Willemijn and Liane Preu{\ss}ner and Rios, {Anne C} and Karsten Rippe and Peter Sandford and Sgourakis, {Nikolaos G} and Adam Shlien and Pete Smith and Karin Straathof and Sullivan, {Patrick J} and Suv{\`a}, {Mario L} and Taylor, {Michael D} and Emma Thompson and Roser Vento-Tormo and Wainwright, {Brandon J} and Wechsler-Reya, {Robert J} and Frank Westermann and Shannon Winslade and Bissan Al-Lazikani and Pfister, {Stefan M}",

note = "{\textcopyright}2024 American Association for Cancer Research.",

year = "2024",

month = jan,

doi = "10.1158/2159-8290.CD-23-1500",

language = "English",

volume = "14",

pages = "663--668",

journal = "Cancer discovery",

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Gilbertson, RJ, Behjati, S, Böttcher, A-L, Bronner, ME, Burridge, M, Clausing, H, Clifford, H, Danaher, T, Donovan, LK, Drost, J , Eggermont, AMM, Emerson, C, Flores, MG, Hamerlik, P, Jabado, N, Jones, A, Kaessmann, H, Kleinman, CL, Kool, M, Kutscher, LM, Lindberg, G, Linnane, E, Marioni, JC, Maris, JM, Monje, M, Macaskill, A, Niederer, S, Northcott, PA, Peeters, E, Plieger-van Solkema, W, Preußner, L, Rios, AC, Rippe, K, Sandford, P, Sgourakis, NG, Shlien, A, Smith, P, Straathof, K, Sullivan, PJ, Suvà, ML, Taylor, MD, Thompson, E, Vento-Tormo, R, Wainwright, BJ, Wechsler-Reya, RJ, Westermann, F, Winslade, S, Al-Lazikani, B & Pfister, SM 2024, 'The Virtual Child', Cancer discovery, vol. 14, no. 4, pp. 663-668. https://doi.org/10.1158/2159-8290.CD-23-1500

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AU - Gilbertson, Richard J

AU - Behjati, Sam

AU - Böttcher, Anna-Lisa

AU - Bronner, Marianne E

AU - Burridge, Matthew

AU - Clausing, Henrick

AU - Clifford, Harry

AU - Danaher, Tracey

AU - Donovan, Laura K

AU - Drost, Jarno

AU - Eggermont, Alexander M M

AU - Emerson, Chris

AU - Flores, Mona G

AU - Hamerlik, Petra

AU - Jabado, Nada

AU - Jones, Andrew

AU - Kaessmann, Henrick

AU - Kleinman, Claudia L

AU - Kool, Marcel

AU - Kutscher, Lena M

AU - Lindberg, Gavin

AU - Linnane, Emily

AU - Marioni, John C

AU - Maris, John M

AU - Monje, Michelle

AU - Macaskill, Alexandra

AU - Niederer, Steven

AU - Northcott, Paul A

AU - Peeters, Elizabeth

AU - Plieger-van Solkema, Willemijn

AU - Preußner, Liane

AU - Rios, Anne C

AU - Rippe, Karsten

AU - Sandford, Peter

AU - Sgourakis, Nikolaos G

AU - Shlien, Adam

AU - Smith, Pete

AU - Straathof, Karin

AU - Sullivan, Patrick J

AU - Suvà, Mario L

AU - Taylor, Michael D

AU - Thompson, Emma

AU - Vento-Tormo, Roser

AU - Wainwright, Brandon J

AU - Wechsler-Reya, Robert J

AU - Westermann, Frank

AU - Winslade, Shannon

AU - Al-Lazikani, Bissan

AU - Pfister, Stefan M

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AB - We are building the world's first Virtual Child-a computer model of normal and cancerous human development at the level of each individual cell. The Virtual Child will "develop cancer" that we will subject to unlimited virtual clinical trials that pinpoint, predict, and prioritize potential new treatments, bringing forward the day when no child dies of cancer, giving each one the opportunity to lead a full and healthy life.

KW - Humans

KW - Neoplasms/genetics

UR - https://www.mendeley.com/catalogue/11b96987-3685-34e5-9fa4-895f50dfda54/

U2 - 10.1158/2159-8290.CD-23-1500

DO - 10.1158/2159-8290.CD-23-1500

M3 - Article

C2 - 38571421

SN - 2159-8274

VL - 14

SP - 663

EP - 668

JO - Cancer discovery

JF - Cancer discovery

IS - 4

ER -

The Virtual Child

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Keywords

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