The Yin and Yang of RNA Methylation: An Imbalance of Erasers Enhances Sensitivity to FTO Demethylase Small-Molecule Targeting in Leukemia Stem Cells

Inge Van Der Werf; Catriona Jamieson

doi:10.1016/j.ccell.2019.03.011

The Yin and Yang of RNA Methylation: An Imbalance of Erasers Enhances Sensitivity to FTO Demethylase Small-Molecule Targeting in Leukemia Stem Cells

Inge Van Der Werf
, Catriona Jamieson

Research output: Contribution to journal › Short survey › peer-review

20 Citations (Scopus)

Abstract

A prevalent eukaryotic N⁶-methyladensosine (m⁶A) post-transcriptional mark can be “erased” by the m⁶A demethylase FTO, which is commonly deregulated in acute myeloid leukemia (AML). In this issue of Cancer Cell, Huang et al. design small-molecule FTO inhibitors, FB23 and FB23-2, and demonstrate their potent inhibitory impact in AML models.

Original language	English
Pages (from-to)	540-541
Number of pages	2
Journal	Cancer Cell
Volume	35
Issue number	4
DOIs	https://doi.org/10.1016/j.ccell.2019.03.011
Publication status	Published - 15 Apr 2019
Externally published	Yes

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title = "The Yin and Yang of RNA Methylation: An Imbalance of Erasers Enhances Sensitivity to FTO Demethylase Small-Molecule Targeting in Leukemia Stem Cells",

abstract = "A prevalent eukaryotic N6-methyladensosine (m6A) post-transcriptional mark can be “erased” by the m6A demethylase FTO, which is commonly deregulated in acute myeloid leukemia (AML). In this issue of Cancer Cell, Huang et al. design small-molecule FTO inhibitors, FB23 and FB23-2, and demonstrate their potent inhibitory impact in AML models.",

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AU - Van Der Werf, Inge

AU - Jamieson, Catriona

PY - 2019/4/15

Y1 - 2019/4/15

N2 - A prevalent eukaryotic N6-methyladensosine (m6A) post-transcriptional mark can be “erased” by the m6A demethylase FTO, which is commonly deregulated in acute myeloid leukemia (AML). In this issue of Cancer Cell, Huang et al. design small-molecule FTO inhibitors, FB23 and FB23-2, and demonstrate their potent inhibitory impact in AML models.

AB - A prevalent eukaryotic N6-methyladensosine (m6A) post-transcriptional mark can be “erased” by the m6A demethylase FTO, which is commonly deregulated in acute myeloid leukemia (AML). In this issue of Cancer Cell, Huang et al. design small-molecule FTO inhibitors, FB23 and FB23-2, and demonstrate their potent inhibitory impact in AML models.

UR - https://www.scopus.com/pages/publications/85063763421

U2 - 10.1016/j.ccell.2019.03.011

DO - 10.1016/j.ccell.2019.03.011

M3 - Short survey

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AN - SCOPUS:85063763421

SN - 1535-6108

VL - 35

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JF - Cancer Cell

IS - 4

ER -

The Yin and Yang of RNA Methylation: An Imbalance of Erasers Enhances Sensitivity to FTO Demethylase Small-Molecule Targeting in Leukemia Stem Cells

Abstract

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