Therapeutic Drug Monitoring of endoxifen as an alternative for CYP2D6 genotyping in individualizing tamoxifen therapy

Aurelia H.M. de Vries Schultink; Alwin D.R. Huitema; Jos H. Beijnen

doi:10.1016/j.breast.2018.08.100

Therapeutic Drug Monitoring of endoxifen as an alternative for CYP2D6 genotyping in individualizing tamoxifen therapy

Aurelia H.M. de Vries Schultink
, Alwin D.R. Huitema
, Jos H. Beijnen

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Different strategies have been proposed to individualize tamoxifen treatment in order to improve recurrence-free survival in estrogen receptor (ER)-positive breast cancer. To date, the debate remains on which strategy should be used. The objective of this viewpoint is to highlight Therapeutic Drug Monitoring of endoxifen, the active tamoxifen metabolite, as the preferred methodology compared to CYP2D6 genotyping for individualizing tamoxifen therapy for ER-positive breast cancer patients treated in the adjuvant setting.

Original language	English
Pages (from-to)	38-40
Number of pages	3
Journal	Breast
Volume	42
DOIs	https://doi.org/10.1016/j.breast.2018.08.100
Publication status	Published - Dec 2018
Externally published	Yes

Keywords

Endoxifen
Therapeutic Drug Monitoring
Treatment individualization

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10.1016/j.breast.2018.08.100

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title = "Therapeutic Drug Monitoring of endoxifen as an alternative for CYP2D6 genotyping in individualizing tamoxifen therapy",

abstract = "Different strategies have been proposed to individualize tamoxifen treatment in order to improve recurrence-free survival in estrogen receptor (ER)-positive breast cancer. To date, the debate remains on which strategy should be used. The objective of this viewpoint is to highlight Therapeutic Drug Monitoring of endoxifen, the active tamoxifen metabolite, as the preferred methodology compared to CYP2D6 genotyping for individualizing tamoxifen therapy for ER-positive breast cancer patients treated in the adjuvant setting.",

keywords = "Endoxifen, Therapeutic Drug Monitoring, Treatment individualization",

author = "\{de Vries Schultink\}, \{Aurelia H.M.\} and Huitema, \{Alwin D.R.\} and Beijnen, \{Jos H.\}",

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year = "2018",

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doi = "10.1016/j.breast.2018.08.100",

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AU - de Vries Schultink, Aurelia H.M.

AU - Huitema, Alwin D.R.

AU - Beijnen, Jos H.

PY - 2018/12

Y1 - 2018/12

N2 - Different strategies have been proposed to individualize tamoxifen treatment in order to improve recurrence-free survival in estrogen receptor (ER)-positive breast cancer. To date, the debate remains on which strategy should be used. The objective of this viewpoint is to highlight Therapeutic Drug Monitoring of endoxifen, the active tamoxifen metabolite, as the preferred methodology compared to CYP2D6 genotyping for individualizing tamoxifen therapy for ER-positive breast cancer patients treated in the adjuvant setting.

AB - Different strategies have been proposed to individualize tamoxifen treatment in order to improve recurrence-free survival in estrogen receptor (ER)-positive breast cancer. To date, the debate remains on which strategy should be used. The objective of this viewpoint is to highlight Therapeutic Drug Monitoring of endoxifen, the active tamoxifen metabolite, as the preferred methodology compared to CYP2D6 genotyping for individualizing tamoxifen therapy for ER-positive breast cancer patients treated in the adjuvant setting.

KW - Endoxifen

KW - Therapeutic Drug Monitoring

KW - Treatment individualization

UR - https://www.scopus.com/pages/publications/85053153224

U2 - 10.1016/j.breast.2018.08.100

DO - 10.1016/j.breast.2018.08.100

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AN - SCOPUS:85053153224

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ER -

Therapeutic Drug Monitoring of endoxifen as an alternative for CYP2D6 genotyping in individualizing tamoxifen therapy

Abstract

Keywords

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