TY - JOUR
T1 - Therapeutic lymphadenectomy in melanomas of the head and neck
AU - Van De Vrie, Willem
AU - Eggermont, Alexander M.M.
AU - Van Putten, Wim L.J.
AU - Wiggers, Theo
PY - 1993
Y1 - 1993
N2 - This retrospective study describes patients with locoregionally metastasized melanoma of the head and neck. All patients underwent a therapeutic lymph node dissection. The 3‐year survival rate was 35%. Duration of disease‐free interval, number of lymph nodes involved, and extent of neck dissection proved of no influence on survival rates. Locoregional recurrence occurred in 10 patients and always proved to be a sign of systemic dissemination. Ultimately, 19 patients developed systemic disease. More than 40% developed cerebral metastases and the cerebrum was the second most involved site. As cerebral involvement occurs often in head and neck melanoma, a computed tomography or magnetic resonance imaging scan of the brain is recommended in the routine work‐up before lymph node dissection. Furthermore, because the extent of the surgical procedure had no influence on local recurrence rate and overall survival, a selective approach, preserving functional structures, is advocated.
AB - This retrospective study describes patients with locoregionally metastasized melanoma of the head and neck. All patients underwent a therapeutic lymph node dissection. The 3‐year survival rate was 35%. Duration of disease‐free interval, number of lymph nodes involved, and extent of neck dissection proved of no influence on survival rates. Locoregional recurrence occurred in 10 patients and always proved to be a sign of systemic dissemination. Ultimately, 19 patients developed systemic disease. More than 40% developed cerebral metastases and the cerebrum was the second most involved site. As cerebral involvement occurs often in head and neck melanoma, a computed tomography or magnetic resonance imaging scan of the brain is recommended in the routine work‐up before lymph node dissection. Furthermore, because the extent of the surgical procedure had no influence on local recurrence rate and overall survival, a selective approach, preserving functional structures, is advocated.
UR - http://www.scopus.com/inward/record.url?scp=0027220681&partnerID=8YFLogxK
U2 - 10.1002/hed.2880150503
DO - 10.1002/hed.2880150503
M3 - Article
C2 - 8407308
AN - SCOPUS:0027220681
SN - 1043-3074
VL - 15
SP - 377
EP - 381
JO - Head and Neck
JF - Head and Neck
IS - 5
ER -