Tissue-Specific DNA Repair Activity of ERCC-1/XPF-1

Mariangela Sabatella; Karen L. Thijssen; Carlota Davó-Martínez; Wim Vermeulen; Hannes Lans

doi:10.1016/j.celrep.2020.108608

Tissue-Specific DNA Repair Activity of ERCC-1/XPF-1

Mariangela Sabatella, Karen L. Thijssen, Carlota Davó-Martínez, Wim Vermeulen, Hannes Lans

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Sabatella et al. image the DNA repair endonuclease ERCC-1/XPF-1 in C. elegans to show that nucleotide excision repair exhibits tissue-specific activity. DNA lesions are very rapidly removed from the entire genome in oocytes but only from transcribed genes in somatic cells. Neurons are more sensitive to DNA damage than muscle cells.

Original language	English
Article number	108608
Journal	Cell Reports
Volume	34
Issue number	2
DOIs	https://doi.org/10.1016/j.celrep.2020.108608
Publication status	Published - 12 Jan 2021
Externally published	Yes

Keywords

C. elegans
CSB
DNA damage response
DNA repair
ERCC1/XPF
nucleotide excision repair
tissue specificity
transcription
transcription-coupled nucleotide excision repair
XPC

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10.1016/j.celrep.2020.108608

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abstract = "Sabatella et al. image the DNA repair endonuclease ERCC-1/XPF-1 in C. elegans to show that nucleotide excision repair exhibits tissue-specific activity. DNA lesions are very rapidly removed from the entire genome in oocytes but only from transcribed genes in somatic cells. Neurons are more sensitive to DNA damage than muscle cells.",

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AU - Vermeulen, Wim

AU - Lans, Hannes

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KW - C. elegans

KW - CSB

KW - DNA damage response

KW - DNA repair

KW - ERCC1/XPF

KW - nucleotide excision repair

KW - tissue specificity

KW - transcription

KW - transcription-coupled nucleotide excision repair

KW - XPC

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Tissue-Specific DNA Repair Activity of ERCC-1/XPF-1

Abstract

Keywords

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