Tissue-Specific DNA Repair Activity of ERCC-1/XPF-1

Mariangela Sabatella, Karen L. Thijssen, Carlota Davó-Martínez, Wim Vermeulen, Hannes Lans

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Sabatella et al. image the DNA repair endonuclease ERCC-1/XPF-1 in C. elegans to show that nucleotide excision repair exhibits tissue-specific activity. DNA lesions are very rapidly removed from the entire genome in oocytes but only from transcribed genes in somatic cells. Neurons are more sensitive to DNA damage than muscle cells.

Original languageEnglish
Article number108608
JournalCell Reports
Volume34
Issue number2
DOIs
Publication statusPublished - 12 Jan 2021
Externally publishedYes

Keywords

  • C. elegans
  • CSB
  • DNA damage response
  • DNA repair
  • ERCC1/XPF
  • nucleotide excision repair
  • tissue specificity
  • transcription
  • transcription-coupled nucleotide excision repair
  • XPC

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