Abstract
Sabatella et al. image the DNA repair endonuclease ERCC-1/XPF-1 in C. elegans to show that nucleotide excision repair exhibits tissue-specific activity. DNA lesions are very rapidly removed from the entire genome in oocytes but only from transcribed genes in somatic cells. Neurons are more sensitive to DNA damage than muscle cells.
Original language | English |
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Article number | 108608 |
Journal | Cell Reports |
Volume | 34 |
Issue number | 2 |
DOIs | |
Publication status | Published - 12 Jan 2021 |
Externally published | Yes |
Keywords
- C. elegans
- CSB
- DNA damage response
- DNA repair
- ERCC1/XPF
- nucleotide excision repair
- tissue specificity
- transcription
- transcription-coupled nucleotide excision repair
- XPC