Abstract
Lymphoid differentiation is one of the best studied examples of mammalian development. Here Hans Clevers and Michael Owen describe how the cloning of the genes that encode T-cell-specific membrane proteins allows the identification of transcription factors that control the expression of these T-cell genes. Such transcription factors play a key role in the development of the mature T-cell phenotype by functioning as 'master regulators of T-cell differentiation'.
Original language | English |
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Pages (from-to) | 86-92 |
Number of pages | 7 |
Journal | Immunology Today |
Volume | 12 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 1991 |
Externally published | Yes |