Towards a molecular understanding of T-cell differentiation

Hans C. Clevers, Michael J. Owen

Research output: Contribution to journalReview articlepeer-review

29 Citations (Scopus)

Abstract

Lymphoid differentiation is one of the best studied examples of mammalian development. Here Hans Clevers and Michael Owen describe how the cloning of the genes that encode T-cell-specific membrane proteins allows the identification of transcription factors that control the expression of these T-cell genes. Such transcription factors play a key role in the development of the mature T-cell phenotype by functioning as 'master regulators of T-cell differentiation'.

Original languageEnglish
Pages (from-to)86-92
Number of pages7
JournalImmunology Today
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 1991
Externally publishedYes

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