TY - JOUR
T1 - Tractography demonstrates dentate-rubro-thalamic tract disruption in an adult with cerebellar mutism
AU - Van Baarsen, Kirsten
AU - Kleinnijenhuis, Michiel
AU - Konert, Tom
AU - Van Cappellen Van Walsum, Anne Marie
AU - Grotenhuis, André
PY - 2013/10
Y1 - 2013/10
N2 - A 55-year-old female is presented with transient cerebellar mutism caused by a well-circumscribed left pontine infarction due to postoperative basilar perforator occlusion. Although conventional T2 imaging shows a welldemarcated lesion confined to the pontine region, diffusion tensor imaging shows an asymmetry in fractional anisotropy in the superior cerebellar peduncle. This supports the general hypothesis that cerebellar mutism is caused by functional disruption of the dentate-rubro-thalamic tract. Correlating postoperative anatomic changes to a heterogenic clinical syndrome remains challenging, however.
AB - A 55-year-old female is presented with transient cerebellar mutism caused by a well-circumscribed left pontine infarction due to postoperative basilar perforator occlusion. Although conventional T2 imaging shows a welldemarcated lesion confined to the pontine region, diffusion tensor imaging shows an asymmetry in fractional anisotropy in the superior cerebellar peduncle. This supports the general hypothesis that cerebellar mutism is caused by functional disruption of the dentate-rubro-thalamic tract. Correlating postoperative anatomic changes to a heterogenic clinical syndrome remains challenging, however.
KW - Cerebellar mutism
KW - Dentate-rubrothalamic (DRT) tract
KW - Pons
KW - Posterior fossa syndrome (PFS)
KW - Superior cerebellar peduncle (SCP)
KW - Tractography
UR - http://www.scopus.com/inward/record.url?scp=84889264971&partnerID=8YFLogxK
U2 - 10.1007/s12311-013-0473-z
DO - 10.1007/s12311-013-0473-z
M3 - Article
C2 - 23546861
AN - SCOPUS:84889264971
SN - 1473-4222
VL - 12
SP - 617
EP - 622
JO - Cerebellum
JF - Cerebellum
IS - 5
ER -