Transcription-coupled repair and premature ageing

J. O. Andressoo, J. H.J. Hoeijmakers

Research output: Contribution to journalReview articlepeer-review

61 Citations (Scopus)

Abstract

During the past decades, several cellular pathways have been discovered to be connected with the ageing process. These pathways, which either suppress or enhance the ageing process, include regulation of the insulin/growth hormone axis, pathways involved with caloric restriction, ROS metabolism and DNA repair. In this review, we will provide a comprehensive overview of cancer and/or accelerated ageing pathologies associated with defects in the multi-step nucleotide excision repair pathway. Moreover, we will discuss evidence suggesting that there is a causative link between transcription-coupled repair and ageing.

Original languageEnglish
Pages (from-to)179-194
Number of pages16
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume577
Issue number1-2 SPEC. ISS.
DOIs
Publication statusPublished - 4 Sept 2005
Externally publishedYes

Keywords

  • Biology of ageing
  • NER-associated disease
  • Transcription-coupled repair

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