TY - JOUR
T1 - Transcription-coupled repair and premature ageing
AU - Andressoo, J. O.
AU - Hoeijmakers, J. H.J.
N1 - Funding Information:
Special thanks to N.G.J. Jaspers, J. Mitchell, G. Garinis and S. Bergink for helpful discussions. This work was financially supported by the Netherlands Organization for Scientific Research (NWO) through the foundation of the Research Institute Diseases of the Elderly, as well as grants from the NIH (1PO1 AG17242-02), NIEHS (1UO1 ES011044), EC (QRTL-1999-02002), and the Dutch Cancer Society (EUR 99-2004).
PY - 2005/9/4
Y1 - 2005/9/4
N2 - During the past decades, several cellular pathways have been discovered to be connected with the ageing process. These pathways, which either suppress or enhance the ageing process, include regulation of the insulin/growth hormone axis, pathways involved with caloric restriction, ROS metabolism and DNA repair. In this review, we will provide a comprehensive overview of cancer and/or accelerated ageing pathologies associated with defects in the multi-step nucleotide excision repair pathway. Moreover, we will discuss evidence suggesting that there is a causative link between transcription-coupled repair and ageing.
AB - During the past decades, several cellular pathways have been discovered to be connected with the ageing process. These pathways, which either suppress or enhance the ageing process, include regulation of the insulin/growth hormone axis, pathways involved with caloric restriction, ROS metabolism and DNA repair. In this review, we will provide a comprehensive overview of cancer and/or accelerated ageing pathologies associated with defects in the multi-step nucleotide excision repair pathway. Moreover, we will discuss evidence suggesting that there is a causative link between transcription-coupled repair and ageing.
KW - Biology of ageing
KW - NER-associated disease
KW - Transcription-coupled repair
UR - http://www.scopus.com/inward/record.url?scp=24044532209&partnerID=8YFLogxK
U2 - 10.1016/j.mrfmmm.2005.04.004
DO - 10.1016/j.mrfmmm.2005.04.004
M3 - Review article
C2 - 16009385
AN - SCOPUS:24044532209
SN - 0027-5107
VL - 577
SP - 179
EP - 194
JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
IS - 1-2 SPEC. ISS.
ER -